지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한외과학회 Annals of Surgical Treatment and Research Annals of Surgical Treatment and Research Vol.100 No.1
- 발행연도
- 2021.1
- 수록면
- 33 - 39 (7page)
이용수
초록· 키워드
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Purpose: CEA is a useful tumor marker for colon cancer. The aim of this study was to investigate the prognostic value of changes in CEA levels before and after surgery in colon cancer patients who underwent radical surgery.
Methods: A total of 601 colon cancer patients who underwent radical surgery from January 2007 to December 2017 at a single institution were evaluated. Patients were categorized according to preoperative and postoperative CEA levels. We adjusted patient characteristics using propensity score matched analysis between groups and compared survival outcomes according to changes in CEA levels before and after surgery.
Results: According to the preoperative and postoperative CEA levels, patients were classified into 3 groups: group 1, ≤5 and ≤5 ng/mL, respectively (n = 407); group 2, >5 and ≤5 ng/mL, respectively (n = 127); and group 3 (>5 and >5 ng/mL, respectively (n = 67). Postoperative CEA elevation was associated with adverse clinical features. Before and after matching, the patients in group 3 showed significantly lower disease-free survival and overall survival rates compared to the patients in group 1 and group 2. In multivariate analysis, changes in CEA levels were an independent prognostic factor of overall survival (P = 0.041).
Conclusion: The changes in CEA levels before and after surgery can be a useful prognostic factor for disease-free survival and overall survival in colon cancer patients.
Methods: A total of 601 colon cancer patients who underwent radical surgery from January 2007 to December 2017 at a single institution were evaluated. Patients were categorized according to preoperative and postoperative CEA levels. We adjusted patient characteristics using propensity score matched analysis between groups and compared survival outcomes according to changes in CEA levels before and after surgery.
Results: According to the preoperative and postoperative CEA levels, patients were classified into 3 groups: group 1, ≤5 and ≤5 ng/mL, respectively (n = 407); group 2, >5 and ≤5 ng/mL, respectively (n = 127); and group 3 (>5 and >5 ng/mL, respectively (n = 67). Postoperative CEA elevation was associated with adverse clinical features. Before and after matching, the patients in group 3 showed significantly lower disease-free survival and overall survival rates compared to the patients in group 1 and group 2. In multivariate analysis, changes in CEA levels were an independent prognostic factor of overall survival (P = 0.041).
Conclusion: The changes in CEA levels before and after surgery can be a useful prognostic factor for disease-free survival and overall survival in colon cancer patients.
목차
INTRODUCTION
METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (28)
참고문헌 신청
Goldstein MJ / 2005 / Carcinoembryonic antigen in the staging and followup of patients with colorectal cancer / Cancer Invest 23:338~351
Hammarström S / 1999 / he carcinoembryonic antigen (CEA) family: structures, suggested functions and expression in normal and malignant tissues / Semin Cancer Biol 9:67~81
Hao C / 2019 / Serum CEA levels in 49 different types of cancer and noncancer diseases / Prog Mol Biol Transl Sci 162:213~227
Chapman MA / 1998 / Preoperative carcinoembryonic antigen is related to tumour stage and long-term survival in colorectal cancer / Br J Cancer 78:1346~1349
Thirunavukarasu P / 2011 / C-stage in colon cancer: implications of carcinoembryonic antigen biomarker in staging, prognosis, and management / J Natl Cancer Inst 103:689~697
Hammarström S / 1999 / he carcinoembryonic antigen (CEA) family: structures, suggested functions and expression in normal and malignant tissues / Semin Cancer Biol 9:67~81
Hao C / 2019 / Serum CEA levels in 49 different types of cancer and noncancer diseases / Prog Mol Biol Transl Sci 162:213~227
Chapman MA / 1998 / Preoperative carcinoembryonic antigen is related to tumour stage and long-term survival in colorectal cancer / Br J Cancer 78:1346~1349
Thirunavukarasu P / 2011 / C-stage in colon cancer: implications of carcinoembryonic antigen biomarker in staging, prognosis, and management / J Natl Cancer Inst 103:689~697
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UCI(KEPA) : I410-ECN-0101-2021-514-001414490