A Review of the Role of Carcinoembryonic Antigen in Clinical Practice

Claire Hall; Louise Clarke; Atanu Pal; Pamela Buchwald; Tim Eglinton; Chris Wakeman; Frank Frizelle

추천

검색

자료유형: 학술저널

저자정보: Claire Hall (University of Otago) Louise Clarke (University of Otago) Atanu Pal (University of Otago) Pamela Buchwald (University of Otago) Tim Eglinton (University of Otago) Chris Wakeman (University of Otago) Frank Frizelle (University of Otago)

저널정보: 대한대장항문학회 Annals of Coloproctology Annals of Coloproctolgy Vol.35 No.6

발행연도: 2019.1

수록면: 294 - 305 (12page)

이용수

📌

연구주제

📖

연구배경

🔬

연구방법

🏆

연구결과

초록· 키워드

오류제보하기

Carcinoembryonic antigen (CEA) is not normally produced in significant quantities after birth but is elevated in colorectal cancer. The aim of this review was to define the current role of CEA and how best to investigate patients with elevated CEA levels. A systematic review of CEA was performed, in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Studies were identified from PubMed, Cochrane library, and controlled trials registers. We identified 2,712 papers of which 34 were relevant. Analysis of these papers found higher preoperative CEA levels were associated with advanced or metastatic disease and thus poorer prognosis. Postoperatively, failure of CEA to return to normal was found to be indicative of residual or recurrent disease. However, measurement of CEA levels alone was not sufficient to improve survival rates. Two algorithms are proposed to guide investigation of patients with elevated CEA: one for patients with elevated CEA after CRC resection, and another for patients with de novo elevated CEA. CEA measurement has an important role in the investigation, management and follow-up of patients with colorectal cancer.

#Carcinoembryonic antigen #Colorectal cancer #Recurrence

참고문헌 (60)

참고문헌 신청

Gold P / 1965 / Demonstration of tumor-specific antigens in human colonic carcinomata by immunological tolerance and absorption techniques / J Exp Med 121:439~462

Thomson DM / 1969 / The radioimmunoassay of circulating carcinoembryonic antigen of the human digestive system / Proc Natl Acad Sci U S A 64:161~167

Becerra AZ / 2016 / Evaluating the prognostic role of elevated preoperative carcinoembryonic antigen levels in colon cancer patients : results from the national cancer database / Ann Surg Oncol 23:1554~1561

Ozawa H / 2017 / Incorporation of serum carcinoembryonic antigen levels into the prognostic grouping system of colon cancer / Int J Colorectal Dis 32:821~829

Spindler BA / 2017 / Incorporation of CEA improves risk stratification in stage II colon cancer / J Gastrointest Surg 21:770~777

함께 읽어보면 좋을 논문

논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!