지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Objectives: The objective of this study is to demonstrate the cardioprotective effects of Salvia Miltiorrhiza Radix (SMR) on the pressure overload (PO)-induced heart failure (HF) by transverse aortic constriction (TAC) in C57BL/6 mice through possible antioxidant effects.
Methods: The mortality, body and heart weights, antioxidant defense system of the heart and histopathology of heart were analyzed. The obtained results were compared with resveratrol, in which potent cardioprotective effects on TAC mice model were already proved at a dose level of 10 mg/kg by antioxidant effects, as reference in this experiment.
Results: Significant increases of mortalities, heart weights, and hypertrophic, lytic and focal fibrotic histological changes in the left ventricles were found with defects of heart antioxidant defense systems – the increases of heart cortex MDA contents, decreases of GSH contents, SOD and CAT activities in TAC control mice as compared with sham vehicle control mice, respectively. However, these HF signs induced by TAC surgery through PO and destroys heart antioxidant defense systems were significantly and dose-dependently inhibited by 14 days continuous oral treatment of SMR 500, 250 and 125 mg/kg, similar to those of resveratrol 10 mg/kg in SMR 125 mg/kg.
Conclusions: The results obtained in this study propose that oral administration of SMR potently alleviates PO-induced HF by TAC, through augmentation of heart antioxidant defense system.
Methods: The mortality, body and heart weights, antioxidant defense system of the heart and histopathology of heart were analyzed. The obtained results were compared with resveratrol, in which potent cardioprotective effects on TAC mice model were already proved at a dose level of 10 mg/kg by antioxidant effects, as reference in this experiment.
Results: Significant increases of mortalities, heart weights, and hypertrophic, lytic and focal fibrotic histological changes in the left ventricles were found with defects of heart antioxidant defense systems – the increases of heart cortex MDA contents, decreases of GSH contents, SOD and CAT activities in TAC control mice as compared with sham vehicle control mice, respectively. However, these HF signs induced by TAC surgery through PO and destroys heart antioxidant defense systems were significantly and dose-dependently inhibited by 14 days continuous oral treatment of SMR 500, 250 and 125 mg/kg, similar to those of resveratrol 10 mg/kg in SMR 125 mg/kg.
Conclusions: The results obtained in this study propose that oral administration of SMR potently alleviates PO-induced HF by TAC, through augmentation of heart antioxidant defense system.
목차
Introduction
Materials and Methods
Results
Discussion
Conclusion
Reference
참고문헌 (40)
참고문헌 신청
[학술지(정기간행물)] - Juric D / 2007 / Prevention of concentric hypertrophy and diastolic impairment in aortic-banded rats treated with resveratrol / Am J Physiol Heart Circ Physiol 292 : 2138 ~ 2143
[학술지(정기간행물)] - Frey N / 2003 / Cardiac hypertrophy : the good, the bad, and the ugly / Annu Rev Physiol 65 : 45 ~ 79
[학술지(정기간행물)] - Gersh BJ / 2011 / American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. 2011ACCF/AHA Guideline for the Diagnosis and Treatment of Hypertrophic Cardiomyopathy: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. Developed in collaboration with the American Association for Thoracic Surgery, American Society of Echocardiography, American Society of Nuclear Cardiology, Heart Failure Society of America, Heart Rhythm Society, Society for Cardiovascular Angiography and Interventions, and Society of Thoracic Surgeons / J. Am. Coll. Cardiol 58 : e212 ~
[학술지(정기간행물)] - Yu S / 2010 / MicroRNA expression and function in cardiac ischemic injury / J Cardiovasc. Transl. Res 3 (3) : 241 ~ 245
[학술지(정기간행물)] - Saletu B / 1995 / Nicergoline in senile dementia of Alzheimer type and multi-infarct dementia : a double-blind, placebo-controlled, clinical and EEG/ERP mapping study / Psychopharmacology 117 (4) : 385 ~ 395
[학술지(정기간행물)] - Frey N / 2003 / Cardiac hypertrophy : the good, the bad, and the ugly / Annu Rev Physiol 65 : 45 ~ 79
[학술지(정기간행물)] - Gersh BJ / 2011 / American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. 2011ACCF/AHA Guideline for the Diagnosis and Treatment of Hypertrophic Cardiomyopathy: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. Developed in collaboration with the American Association for Thoracic Surgery, American Society of Echocardiography, American Society of Nuclear Cardiology, Heart Failure Society of America, Heart Rhythm Society, Society for Cardiovascular Angiography and Interventions, and Society of Thoracic Surgeons / J. Am. Coll. Cardiol 58 : e212 ~
[학술지(정기간행물)] - Yu S / 2010 / MicroRNA expression and function in cardiac ischemic injury / J Cardiovasc. Transl. Res 3 (3) : 241 ~ 245
[학술지(정기간행물)] - Saletu B / 1995 / Nicergoline in senile dementia of Alzheimer type and multi-infarct dementia : a double-blind, placebo-controlled, clinical and EEG/ERP mapping study / Psychopharmacology 117 (4) : 385 ~ 395
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UCI(KEPA) : I410-ECN-0101-2017-519-001005780