지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.10
- 수록면
- 305 - 310 (6page)
이용수
초록· 키워드
오류제보하기
In this study, we compared two different tumor cell vaccines for their induction of anti-tumor immunity; one was a tumor cell clone expressing a membrane-bound form of IL-12 p35 subunit (mbIL-12 p35 tumor clone), and the other was a tumor clone expressing heterodimeric IL-12 as a single chain (mb-scIL-12 tumor clone). The stimulatory effect of mb-scIL-12 on the proliferation of ConA-activated splenocytes was higher than that of mbIL-12 p35 in vitro. However, the stimulatory effect of mbIL-12 p35 was equivalent to that of recombinant soluble IL-12 (3 ng/ml). Interestingly, both tumor clones (mbIL-12 p35 and mb-scIL-12) showed similar tumorigenicity and induction of systemic anti-tumor immunity in vivo, suggesting that tumor cell expression of the membrane-bound p35 subunit is sufficient to induce anti-tumor immunity in our tumor vaccine model.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS AND DISCUSSION
REFERENCES
참고문헌 (24)
참고문헌 신청
[학술지(정기간행물)] - Schoenhaut, D. S. / 1992 / Cloning and expression of murine IL-12 / J. Immunol 148 : 3433 ~ 3440
[학술지(정기간행물)] - Trinchieri, G / 1994 / Interleukin-12: a cytokine produced by antigen-presenting cells with immunoregulatory functions in the generation of T-helper cells type 1 and cytotoxic lymphocytes / Blood 84 : 4008 ~ 4027
[학술지(정기간행물)] - Hsieh, C. S / 1993 / Development of TH1CD4+ T cells through IL-12 produced by Listeria-induced macrophages / Science 260 : 547 ~ 549
[학술지(정기간행물)] - Gately, M. K / 1994 / Administration of recombinant IL-12 to normal mice enhances cytolytic lymphocyte activity and induces production of IFN-gamma in vivo / Int. Immunol 6 : 157 ~ 167
[학술지(정기간행물)] - Hendrzak, J. A / 1996 / Antitumor and antimetastatic activity of interleukin-12 / Curr. Top. Microbiol. Immunol 213 : 65 ~ 83
[학술지(정기간행물)] - Trinchieri, G / 1994 / Interleukin-12: a cytokine produced by antigen-presenting cells with immunoregulatory functions in the generation of T-helper cells type 1 and cytotoxic lymphocytes / Blood 84 : 4008 ~ 4027
[학술지(정기간행물)] - Hsieh, C. S / 1993 / Development of TH1CD4+ T cells through IL-12 produced by Listeria-induced macrophages / Science 260 : 547 ~ 549
[학술지(정기간행물)] - Gately, M. K / 1994 / Administration of recombinant IL-12 to normal mice enhances cytolytic lymphocyte activity and induces production of IFN-gamma in vivo / Int. Immunol 6 : 157 ~ 167
[학술지(정기간행물)] - Hendrzak, J. A / 1996 / Antitumor and antimetastatic activity of interleukin-12 / Curr. Top. Microbiol. Immunol 213 : 65 ~ 83
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UCI(KEPA) : I410-ECN-0101-2017-517-001663435