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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.12
- 수록면
- 288 - 294 (7page)
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초록· 키워드
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Marine algae exhibit broad spectrum anti-bacterial and anti-inflammatory activities. Acrosorium polyneurum (A. polyneurum) is a marine red alga and belongs to the family Delesseriaceae. The present research evaluates the anti-inflammatory effects of A. polyneurum extract (APE) on pro-inflammatory cytokine production. APE demonstrated substantial inhibitory effects on production of pro-inflammatory cytokine in bone marrow-derived macrophages (BMDMs). APE pre-treatment in the lipopolysaccharide (LPS)-stimulated BMDMs exhibited a robust inhibitory effect on production of interleukin (IL)-12, IL-6 and tumor necrosis factor (TNF)-α. It revealed a robust inhibitory effect on phosphorylation of ERK1/2, JNK1/2 and p38. APE also showed remarkable inhibitory effect on phosphorylation and degradation of IκBα. Furthermore, APE pre-treatment demonstrated substantial inhibition of LPS-induced production of nitric oxide and inducible nitric oxide synthase. Collectively, these data suggest that APE has a noteworthy anti-inflammatory property and deserve further studies concerning its potential use as a medicinal agent for inflammation-related disorders.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS AND DISCUSSION
REFERENCES
참고문헌 (27)
참고문헌 신청
[학술지(정기간행물)] - Takeuchi O / 2010 / Pattern recognition receptors and inflammation / Cell 140 : 805 ~ 820
[학술지(정기간행물)] - Zahid Manzoor / 2012 / Mitogen-activated Protein Kinases in Inflammation / Journal of Bacteriology and Virology 42 (3) : 189 ~ 195
[학술지(정기간행물)] - 고영상 / 2011 / Nucleic Acid Recognition and Signaling by Toll-like Receptor 9: Compartment-dependent Regulation / Journal of Bacteriology and Virology 41 (2) : 131 ~ 132
[학술지(정기간행물)] - Efron PA / 2005 / Differential maturation of murine bone-marrow derived dendritic cells with lipopolysaccharide and tumor necrosis factor-α / J Endotoxin Res 11 : 145 ~ 160
[학술지(정기간행물)] - Zahid Manzoor / 2014 / Mitogen-activated Protein Kinase Signaling in Inflammation-related Carcinogenesis / Journal of Bacteriology and Virology 44 (4) : 297 ~ 304
[학술지(정기간행물)] - Zahid Manzoor / 2012 / Mitogen-activated Protein Kinases in Inflammation / Journal of Bacteriology and Virology 42 (3) : 189 ~ 195
[학술지(정기간행물)] - 고영상 / 2011 / Nucleic Acid Recognition and Signaling by Toll-like Receptor 9: Compartment-dependent Regulation / Journal of Bacteriology and Virology 41 (2) : 131 ~ 132
[학술지(정기간행물)] - Efron PA / 2005 / Differential maturation of murine bone-marrow derived dendritic cells with lipopolysaccharide and tumor necrosis factor-α / J Endotoxin Res 11 : 145 ~ 160
[학술지(정기간행물)] - Zahid Manzoor / 2014 / Mitogen-activated Protein Kinase Signaling in Inflammation-related Carcinogenesis / Journal of Bacteriology and Virology 44 (4) : 297 ~ 304
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UCI(KEPA) : I410-ECN-0101-2017-475-001976765