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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.12
- 수록면
- 1 - 9 (9page)
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초록· 키워드
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Objectives: The aim of this study was to solve skin moisturizing action mechanism issues of pomegranate concentrated solution (PCS) and dried pomegranate concentrate powder (PCP), at least partially.
Materials and methods: In this study, ceramide and TGF-β1 contents with TGF-β1 mRNA expressions were analysis on the skin tissue homogenate samples after 56 days of continuous oral administration of PCS 1, 2, and 4 ml/kg, and PCP 100, 200 and 400 mg/kg.
Results: Noticeable and dose-dependent increases of skin TGF-β1 contents and mRNA expressions were demonstrated in all PCP and PCS treated mice as compared with intact vehicle control, but no significant changes on the skin ceramide contents were demonstrated in all PCP and PCS treated mice as compared with intact vehicle control, in the current study. In addition, PCP 200 mg/kg showed similar increases of the skin TGF-β1 contents and mRNA expressions as compared to those of PCS 4 ml/kg.
Conclusions: The presented results suggested that in vivo skin moisturizing effects of PCP and PCS after oral administration through up regulation of hyaluronan synthesis demonstrated in our previous results, may be possibly mediated by modulation of TGF-β1 expressions at least partially, without critical influences on the skin ceramide contents.
Materials and methods: In this study, ceramide and TGF-β1 contents with TGF-β1 mRNA expressions were analysis on the skin tissue homogenate samples after 56 days of continuous oral administration of PCS 1, 2, and 4 ml/kg, and PCP 100, 200 and 400 mg/kg.
Results: Noticeable and dose-dependent increases of skin TGF-β1 contents and mRNA expressions were demonstrated in all PCP and PCS treated mice as compared with intact vehicle control, but no significant changes on the skin ceramide contents were demonstrated in all PCP and PCS treated mice as compared with intact vehicle control, in the current study. In addition, PCP 200 mg/kg showed similar increases of the skin TGF-β1 contents and mRNA expressions as compared to those of PCS 4 ml/kg.
Conclusions: The presented results suggested that in vivo skin moisturizing effects of PCP and PCS after oral administration through up regulation of hyaluronan synthesis demonstrated in our previous results, may be possibly mediated by modulation of TGF-β1 expressions at least partially, without critical influences on the skin ceramide contents.
목차
Introduction
Materials and methods
Results
Discussion
References
참고문헌 (40)
참고문헌 신청
Sugiyama Y / 1998 / Putative hyaluronan synthase mRNA are expressed in mouse skin and TGF-b upregulates their expression in cultured human skin cells / J Invest Dermatol 110(2):116~121
Laurent TC / 1992 / Hyaluronan / Faseb J 6(7):2397~2404
Laurent UBG / 1991 / Hyaluronic Acid in Controlled Drug Delivery Turnover of hyaluronan in the tissues / Advanced Drug Delivery Rev 7(2):237~256
Tammi R / 1988 / Localization of epidermal hyaluronic acid using the hyaluronate binding region of cartilage proteoglycan as a specific probe / J Invest Dermatol 90(3):412~414
Brown KW / 1983 / Glycoproteins and glycosaminoglycans of cultured normal human epidermal keratinocytes / Journal of cell science 61:325~338
Laurent TC / 1992 / Hyaluronan / Faseb J 6(7):2397~2404
Laurent UBG / 1991 / Hyaluronic Acid in Controlled Drug Delivery Turnover of hyaluronan in the tissues / Advanced Drug Delivery Rev 7(2):237~256
Tammi R / 1988 / Localization of epidermal hyaluronic acid using the hyaluronate binding region of cartilage proteoglycan as a specific probe / J Invest Dermatol 90(3):412~414
Brown KW / 1983 / Glycoproteins and glycosaminoglycans of cultured normal human epidermal keratinocytes / Journal of cell science 61:325~338
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UCI(KEPA) : I410-ECN-0101-2017-519-002364948