지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한소아혈액종양학회 Clinical Pediatric Hematology-Oncology Clinical Pediatric Hematology-Oncology Vol.25 No.2
- 발행연도
- 2018.1
- 수록면
- 154 - 161 (8page)
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Background: Pneumocystis is difficult to culture or detect in laboratory environments. Its ecology including the timing and method of transmission as well as environmental sources and communicability remain unclear. Methods: We retrospectively evaluated the pattern and treatment outcome of Pneumocystis jirovecii pneumonia (PCP) in children with acute lymphoblastic leukemia (ALL) who received chemotherapy. Results: A total of 56 patients with ALL were evaluated. While on chemotherapy, all patients received PCP prophylaxis. PCP were found in a total of 6 patients, including definite PCP in 2, probable PCP in 2, and possible PCP in 2 patients. There were no significant differences in sex, age group, National Cancer Institute risk group, or pneumocystis prophylaxis type between PCP and non-PCP groups. However, there was a significant statistical difference in the times of ALL diagnosis. Regarding recent chemotherapy at the time of PCP diagnosis, there were one induction, one consolidation, and four maintenance cases. All PCP patients were treated with high-dose sulfamethoxazole (100 mg/kg/day) and trimethoprim (20 mg/kg/day) intravenously. Five patients survived, while one patient with endotracheal mechanical ventilation therapy died due to respiratory failure in spite of aggressive treatment. Conclusion: Pediatric PCP became extremely rare due to routine prophylaxis in clinical practice of pediatric malignancy. Nevertheless, we analyzed patients with acute lymphoblastic leukemia who had received PCP prophylaxis for 14 years, and analyzed the clustered outbreaks of PCP. It is still important to emphasize the need for prophylaxis and to increase the level of attention and isolation under environmental and personal risk factors.
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참고문헌 (3)
참고문헌 신청
김경란 / 2016 / Pneumocystis jirovecii pneumonia in pediatric patients: an analysis of 15 confirmed consecutive cases during 14 years / Korean Journal of Pediatrics 59(6):252~256
김서희 / 2016 / 소아 주폐포자충 폐렴의 임상양상, 위험인자 및 예방요법의 효과 연구 / Pediatric Infection and Vaccine 23(1):31~39
Grant LR / 2012 / Procedures for collection of induced sputum specimens from children / Clin Infect Dis 54(Suppl 2):S140~S145
김서희 / 2016 / 소아 주폐포자충 폐렴의 임상양상, 위험인자 및 예방요법의 효과 연구 / Pediatric Infection and Vaccine 23(1):31~39
Grant LR / 2012 / Procedures for collection of induced sputum specimens from children / Clin Infect Dis 54(Suppl 2):S140~S145
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