지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Objectives: The aim of this study was to confirm the dose-dependent skin moisturizing effects of dried pomegranate concentrate powder (PCP) and pomegranate concentrate solution (PCS) in ICR mice.
Materials and methods: To observe the in vivo skin moisturizing effects and possible underlying mechanisms of PCP and PCS, oral PCP (100, 200, and 400 mg/kg) and PCS (1, 2, and 4 mL/kg) were administered to normal ICR mice. Changes in body weight, skin water content, and skin type I collagen and hyaluronan contents were measured. Additionally, the mRNA expression levels of hyaluronan synthase (Has) 1, 2, and 3, and collagen type I alpha (COL1A) 1 and 2 were determined in the dorsal skin of mice by real-time reverse transcription polymerase chain reaction (RT-PCR).
Results: Significant and dose-dependent increases in dorsal skin water content and type I collagen and hyaluronan contents were seen in PCP and PCS-treated mice. Moreover, the mRNA levels of Has 1, 2, and 3, involved in hyaluronan synthesis, and of COL1A1 and COL1A2, involved in collagen synthesis, were significantly and dose-dependently upregulated in PCS- and PCP-treated mice.
Conclusions: In this study, PCP and PCS led to favorable skin moisturizing effects as indicated by increased skin water content and the upregulation of hyaluronan and collagen synthesis enzymes in mice treated with PCS (4 mL/kg) and PCP (200 mg/kg).
Materials and methods: To observe the in vivo skin moisturizing effects and possible underlying mechanisms of PCP and PCS, oral PCP (100, 200, and 400 mg/kg) and PCS (1, 2, and 4 mL/kg) were administered to normal ICR mice. Changes in body weight, skin water content, and skin type I collagen and hyaluronan contents were measured. Additionally, the mRNA expression levels of hyaluronan synthase (Has) 1, 2, and 3, and collagen type I alpha (COL1A) 1 and 2 were determined in the dorsal skin of mice by real-time reverse transcription polymerase chain reaction (RT-PCR).
Results: Significant and dose-dependent increases in dorsal skin water content and type I collagen and hyaluronan contents were seen in PCP and PCS-treated mice. Moreover, the mRNA levels of Has 1, 2, and 3, involved in hyaluronan synthesis, and of COL1A1 and COL1A2, involved in collagen synthesis, were significantly and dose-dependently upregulated in PCS- and PCP-treated mice.
Conclusions: In this study, PCP and PCS led to favorable skin moisturizing effects as indicated by increased skin water content and the upregulation of hyaluronan and collagen synthesis enzymes in mice treated with PCS (4 mL/kg) and PCP (200 mg/kg).
목차
Introduction
Materials and Methods
Results
Discussion
Reference
참고문헌 (32)
참고문헌 신청
[학술지(정기간행물)] - Gilchrest BA / 1990 / Skin aging and photoaging / Dermatol Nurs 2 (2) : 79 ~ 82
[학술지(정기간행물)] - Wiedow O / 1990 / Elafin: an elastase-specific inhibitor of human skin. Purification, characterization, and complete amino acid sequence / J Biol Chem 265 (25) : 14791 ~ 14795
[학술지(정기간행물)] - Maity N / 2011 / Exploring Tagetes erecta Linn flower for the elastase, hyaluronidase and MMP-1 inhibitory activity / J Ethnopharmacol 137 (3) : 1300 ~ 1305
[학술지(정기간행물)] - Chan YY / 2011 / Inhibitory effects of Sargassum polycystum on tyrosinase activity and melanin formation in B16F10murine melanoma cells / J Ethnopharmacol 137 (3) : 1183 ~ 1188
[학술지(정기간행물)] - Imokawa G / 2008 / Recent advances in characterizing biological mechanisms underlying UV-induced wrinkles: a pivotal role of fibrobrast-derived elastase / Arch Dermatol Res 300 (Suppl 1) : 7 ~ 20
[학술지(정기간행물)] - Wiedow O / 1990 / Elafin: an elastase-specific inhibitor of human skin. Purification, characterization, and complete amino acid sequence / J Biol Chem 265 (25) : 14791 ~ 14795
[학술지(정기간행물)] - Maity N / 2011 / Exploring Tagetes erecta Linn flower for the elastase, hyaluronidase and MMP-1 inhibitory activity / J Ethnopharmacol 137 (3) : 1300 ~ 1305
[학술지(정기간행물)] - Chan YY / 2011 / Inhibitory effects of Sargassum polycystum on tyrosinase activity and melanin formation in B16F10murine melanoma cells / J Ethnopharmacol 137 (3) : 1183 ~ 1188
[학술지(정기간행물)] - Imokawa G / 2008 / Recent advances in characterizing biological mechanisms underlying UV-induced wrinkles: a pivotal role of fibrobrast-derived elastase / Arch Dermatol Res 300 (Suppl 1) : 7 ~ 20
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Skin tissue homogenate analysis for ceramide and TGF-β1 contents with TGF-β1 mRNA expressions after treatment of pomegranate concentrated solution and dried pomegranate concentrate powder in mice
대한한의학회지
2016 .12
-
In vitro anti-skin-aging effects of dried pomegranate concentrated powder
대한예방한의학회지
2018 .01
-
풋사과 추출물의 피부 보습 효과
한방안이비인후피부과학회지
2022 .11
-
소아 주폐포자충 폐렴의 임상양상, 위험인자 및예방요법의 효과 연구
Pediatric Infection and Vaccine
2016 .01
-
PCP 함유 폐기물의 열적처리 가능성 연구
환경독성보건학회 심포지엄 및 학술대회
2019 .10
-
Characteristic Features of Pneumocystis Pneumonia in Pediatric Acute Lymphoblastic Leukemia
Clinical Pediatric Hematology-Oncology
2018 .01
-
석류농축액의 광노화에 의한 주름 개선 효과
대한예방한의학회지
2015 .04
-
TGF-β1 upregulates the expression of hyaluronan synthase 2 and hyaluronan synthesis in culture models of equine articular chondrocytes
Journal of Veterinary Science
2018 .11
-
Hyaluronan Drug Delivery Systems are Promising for Cancer Therapy Because of Their Selective Attachment, Enhanced Uptake, and Superior Efficacy
Biomedical Engineering Letters (BMEL)
2015 .01
-
Selection of the optimal herbal composition ofSelection of the optimal herbal composition ofpomegranate concentrated powder from aqueous extracts of Eucommiae Cortex and Achyranthis Radix to treat osteoarthritis in rats
대한한의학회지
2017 .12
-
저분자녹각콜라겐의 피부건강 증진 효과
생약학회지(Korean Journal of Pharmacognosy)
2023 .12
-
부산 지역 한 국립대병원에서의 경피적 심폐체외순환 치료 경험
고신대학교 의과대학 학술지
2015 .01
-
Anti-osteoarthritic effects of a combination of pomegranate concentrate powder, Eucommiae cortex and Achyranthis radix in rats
대한한의학회지
2018 .12
-
Spatiotemporal Clusters and Trends of Pneumocystis Pneumonia in Korea
Parasites, Hosts and Diseases
2022 .10
-
Skin Corrosion and Irritation Test of Nanoparticles Using Reconstructed Three-Dimensional Human Skin Model, EpiDermTM
Toxicological Research
2016 .10
-
Conjugation of pheophorbide A and SN38 with hyaluronan nanoparticles for photodynamic- and cascadic chemotherapy in cancer stem-like ovarian cancer
한국실험동물학회 학술발표대회 논문집
2022 .07
-
Baumann Skin Type in the Korean Male Population
Annals of Dermatology
2019 .01
-
Anti-osteoarthritis effects of Pomegranate, Eucommiae cortex and Achyranthis radix extracts on the primary cultured rat articular chondrocytes
대한예방한의학회지
2017 .01
-
Type 2 Innate Lymphoid Cells and Skin Fibrosis in a Murine Model of Atopic Dermatitis-Like Skin Inflammation
Journal of Korean Medical Science
2024 .08
-
시판 석류음료가 치아 법랑질 표면에 미치는 영향
대한구강보건학회지
2021 .12
이 논문의 저자 정보
이 논문과 함께 이용한 논문
The Effect of Pomegranate Extracts on the Menopausal Syndromes
Hyun Chul Kim
,
Eun Joo Kum
,
Do Hyoung Kwon
외 1명
대한의생명과학회지
2009
.09
석류 농축액을 첨가한 백설기의 품질 특성
최지은
,
이준호
한국식품영양과학회지
2015
.01
석류를 이용한 막걸리의 품질 특성 및 항산화 활성
김난슬
,
안미지
,
최선욱
동아시아식생활학회지
2014
.12
석류 외피 분말을 첨가한 크림수프의 품질 특성
박경태
Culinary Science & Hospitality Research
2010
.09
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2017-519-001005775