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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.9
- 수록면
- 277 - 280 (4page)
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초록· 키워드
오류제보하기
Elsholtzia splendens, which grows on moist soil of mountainous regions, is widely distributed at all regions of Korea, especially at Mountain Ji ri. It is categorized as a Labiatae plant which is dried aerial part. It has the following medicinal properties; removal of fever, alleviation of pain, a good antiphlogistic agent as well as antibacterial effects. However, the effects of E. splendens on thrombosis and platelet activation are not precisely understood. We performed this study to develop antithrombotic agents from oriental medicine herb extracts. E. splendens inhibited platelet aggregation induced by arachidonic acid and U46619 in a concentration dependent manner. E. splendens did not show an effect on anticoagulation as determined by prothrombin time (PT) or activated partial thromboplastin time (aPTT). We also tested the effects of E. splendens using a carotid artery thrombosis rat model induced by 35% FeCl<SUB>3</SUB> treatment. E. splendens significantly inhibited thrombus weight compared with the control group. These results show that E. splendens may be developed as a potential antiplatelet activity agent for treatment of cardiocerebrovascular disease and atherosclerosis.
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등록된 정보가 없습니다.
참고문헌 (11)
참고문헌 신청
Burggraf D, Vosko MR, Schubert M, Stassen JM, Hamann GF. Different therapy options protecting microvasculature after experimental cerebral ischaemia and reperfusion. Thrombosis and Haemostasis. 2010. 103: 891-900.
Chen C, Yang FQ, Zhang Q, Wang FQ, Hu YJ, Xia ZN. Natural products for antithrombosis. Evidence-Based Complementary and Alternative Medicine. 2015: 876426.
Heo J. Donguibogam. Namsandang. 2000. 660.
Jin YR, Im JH, Park ES, Cho MR, Han XH, Lee JJ, Lim Y, Kim TJ, Yun YP. Antiplatelet activity of epigallocatechin gallate is mediated by the inhibition of PLCgamma2 phosphorylation, elevation of PGD2 production, and maintaining calcium- ATPase activity. Journal of Cardiovascular Pharmacology. 2008. 51: 45-54.
Liu S, Jiang S, Wu Z, Lv L, Zhang J, Zhu Z, Wu S. Identification of inhibitors of the HIV-1 gp41 six-helix bundle formation from extracts of Chinese medicinal herbs Prunella vulgaris and Rhizoma cibotte. Life Sciences. 2002. 71: 1779-1791.
Jin YR, Im JH, Park ES, Cho MR, Han XH, Lee JJ, Lim Y, Kim TJ, Yun YP. Antiplatelet activity of epigallocatechin gallate is mediated by the inhibition of PLCgamma2 phosphorylation, elevation of PGD2 production, and maintaining calcium- ATPase activity. Journal of Cardiovascular Pharmacology. 2008. 51: 45-54.
Liu S, Jiang S, Wu Z, Lv L, Zhang J, Zhu Z, Wu S. Identification of inhibitors of the HIV-1 gp41 six-helix bundle formation from extracts of Chinese medicinal herbs Prunella vulgaris and Rhizoma cibotte. Life Sciences. 2002. 71: 1779-1791.
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UCI(KEPA) : I410-ECN-0101-2018-510-001347573