지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.10
- 수록면
- 445 - 452 (8page)
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초록· 키워드
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Background: Red ginseng and ginsenosides have shown plethoric effects against various ailments. However, little is known regarding the effect of red ginseng on morphine-induced dependence and tolerance. We therefore investigated the effect of red ginseng extract (RGE) and biotransformed ginsenosides Rh2, Rg3, and compound K on morphine-induced dependence in mice and rats.
Methods: While mice were pretreated with RGE and then morphine was injected intraperitoneally, rats were infused with ginsenosides and morphine intracranially for 7 days. Naloxone-induced morphine withdrawal syndrome was estimated and conditioned place preference test was performed for physical and psychological dependence, respectively. Western blotting was used to measure protein expressions.
Results: Whereas RGE inhibited the number of naloxone-precipitated jumps and reduced conditioned place preference score, it restored the level of glutathione in mice. Likewise, ginsenosides Rh2, Rg3, and compound K attenuated morphine-dependent behavioral patterns such as teeth chattering, grooming, wet-dog shake, and escape behavior in rats. Moreover, activated N-methyl-D-aspartate acid receptor subunit 1 and extracellular signal-regulated kinase in the frontal cortex of rats, and cultured cortical neurons from mice were downregulated by ginsenosides Rh2, Rg3, and compound K despite their differential effects.
Conclusion: RGE and biotransformed ginsenosides could be considered as potential therapeutic agents against morphine-induced dependence.
Methods: While mice were pretreated with RGE and then morphine was injected intraperitoneally, rats were infused with ginsenosides and morphine intracranially for 7 days. Naloxone-induced morphine withdrawal syndrome was estimated and conditioned place preference test was performed for physical and psychological dependence, respectively. Western blotting was used to measure protein expressions.
Results: Whereas RGE inhibited the number of naloxone-precipitated jumps and reduced conditioned place preference score, it restored the level of glutathione in mice. Likewise, ginsenosides Rh2, Rg3, and compound K attenuated morphine-dependent behavioral patterns such as teeth chattering, grooming, wet-dog shake, and escape behavior in rats. Moreover, activated N-methyl-D-aspartate acid receptor subunit 1 and extracellular signal-regulated kinase in the frontal cortex of rats, and cultured cortical neurons from mice were downregulated by ginsenosides Rh2, Rg3, and compound K despite their differential effects.
Conclusion: RGE and biotransformed ginsenosides could be considered as potential therapeutic agents against morphine-induced dependence.
목차
ABSTRACT
1. Introduction
2. Materials and methods
3. Results
4. Discussion
References
참고문헌 (39)
참고문헌 신청
[학술지(정기간행물)] - Harned M / 2016 / Safety concerns with long-term opioid use / Expert Opin Drug Saf 26 : 1 ~ 8
[학술지(정기간행물)] - Currow DC / 2016 / Using opioids in general practice for chronic noncancer pain: an overview of current evidence / Med J Aust 204 : 305 ~ 309
[학술지(정기간행물)] - Karami M / 2013 / Antinociceptive activity and effect of methanol extracts of three salvia spp. on withdrawal syndrome in mice / Adv Pharm Bull 3 : 457 ~ 459
[학술지(정기간행물)] - Garzon J / 2012 / Direct association of Muopioid and NMDA glutamate receptors supports their cross-regulation: molecular implications for opioid tolerance / Curr Drug Abuse Rev 5 : 199 ~ 226
[학술지(정기간행물)] - Martín F / 2009 / Morphine withdrawal regulates phosphorylation of cAMP response element binding protein (CREB) through PKC in the nucleus tractus solitarius-A2 catecholaminergic neurons / J Neurochem 110 : 1422 ~ 1432
[학술지(정기간행물)] - Currow DC / 2016 / Using opioids in general practice for chronic noncancer pain: an overview of current evidence / Med J Aust 204 : 305 ~ 309
[학술지(정기간행물)] - Karami M / 2013 / Antinociceptive activity and effect of methanol extracts of three salvia spp. on withdrawal syndrome in mice / Adv Pharm Bull 3 : 457 ~ 459
[학술지(정기간행물)] - Garzon J / 2012 / Direct association of Muopioid and NMDA glutamate receptors supports their cross-regulation: molecular implications for opioid tolerance / Curr Drug Abuse Rev 5 : 199 ~ 226
[학술지(정기간행물)] - Martín F / 2009 / Morphine withdrawal regulates phosphorylation of cAMP response element binding protein (CREB) through PKC in the nucleus tractus solitarius-A2 catecholaminergic neurons / J Neurochem 110 : 1422 ~ 1432
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UCI(KEPA) : I410-ECN-0101-2018-524-001598592