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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.2
- 수록면
- 35 - 42 (8page)
- DOI
- 10.15188/kjopp.2018.02.32.1.35
이용수
초록· 키워드
오류제보하기
TRPA1 and TRPV1 are members of the TRP superfamily of structurally related, nonselective cation channels. TRPA1 and TRPV1 are often co-expressed in sensory neurons and play an important role in mechanical hyperalgesia and allodynia during neuropathic pain. Scutellariae Radix was reported to possess anti-inflammation properties and similar patterns of therapeutic action against different diseases. also Baicalin(a known principal constituent of Scutellaria Radix) was shown to down-regulate the mRNA expression levels of TRPV1. In this study, we observed the effects of Scutellariae Radix extract(SRE) in neuropathic pain induced SD rats via modulation of TRPV1 and TRPA1. Oral administration of a Scutellaria Radix extract(in doses of 300mg/㎏, SRE(300)) showed a meaningful increase in the withdrawal threshold of mechanical allodynia and showed a meaningful decrease in the expression of c-fos compared to the control group. SRE(100) and SRE(300) showed a meaningful decrease in the expression of TRPV1 level compared to the control group. These results suggest that Scutellariae Radix extract could decrease mechanical allodynia by down-regulate the TRPV1 on the model of neuropathic pain.
목차
서론
재료 및 방법
결과
고찰
결론
References
참고문헌 (39)
참고문헌 신청
Jensen TS / 2011 / A new definition of neuropathic pain / Pain 152:2204~2205
Maag R / 2006 / Neuropathic pain : translational research and impact for patient care / Curr Pain Headache Rep 10(3):191~198
Devor M / 1983 / Nerve pathophysiology and mechanisms of pain in causalgia / J Auton Nerv syst 7:371~384
Bonica JJ / 1990 / Causalgia and other reflex sympathetic dystrophies. The management of pain / Lea and Febiger Publishers :220~243
R. Baron / 2006 / Mechanisms of disease: neuropathic pain. A clinical perspective / Nature Clinical Practice Neurology 2(2):95~106
Maag R / 2006 / Neuropathic pain : translational research and impact for patient care / Curr Pain Headache Rep 10(3):191~198
Devor M / 1983 / Nerve pathophysiology and mechanisms of pain in causalgia / J Auton Nerv syst 7:371~384
Bonica JJ / 1990 / Causalgia and other reflex sympathetic dystrophies. The management of pain / Lea and Febiger Publishers :220~243
R. Baron / 2006 / Mechanisms of disease: neuropathic pain. A clinical perspective / Nature Clinical Practice Neurology 2(2):95~106
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UCI(KEPA) : I410-ECN-0101-2018-519-001809146