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논문 기본 정보

자료유형
학술저널
저자정보
저널정보
한국식품저장유통학회 Food Science and Preservation 한국식품저장유통학회지 제18권 제4호
발행연도
2011.8
수록면
590 - 596 (7page)

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Pimpinella brachycarpa, called as cham-na-mul in Korea, is an edible popular herb. However, the study of biological activity of P. brachycarpa is still rudimentary in worldwide. In this study, from the cultivated P. brachycarpa, we prepared the methanol extract and its subsequent solvent fractions, and their antimicrobial, antioxidation, and anti-proliferative activities were evaluated. The fraction yields of n-hexane (H), methylene chloride (EC), ethylacetate (EA), butanol (B), and water residue (W) from the methanol extract were 18.71, 0.7, 0.56, 4.57, and 71.51%, respectively. Analysis of total flavonoid and total polyphenol showed that the EA fraction contained the highest contents (89.23 and 200 mg/g), and the W residue has the lowest contents (19.6 and 2.27 mg/g) among the factions. In antimicrobial activity assay, the EA fraction showed a broad-range antibacterial activity, while the H fraction is effective against gram positive bacteria. In antioxidation activity assay, EA and B fraction showed strong DPPH anion and ABTS cation scavenging activities including reducing power, and H and MC fraction showed effective nitrite scavenging activity (71.43~83.82 μg/mL of IC50). In a while, only B fraction showed strong anti-proliferative activity against human colorectal cancer HCT-116 (166 μg/mL of IC50) as a dose-dependent manner up to 200 μg/mL. These results suggest that the EA and B fraction of P. brachycarpa could be developed as functional food ingredients.

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UCI(KEPA) : I410-ECN-0101-2018-059-003064826