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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.10
- 수록면
- 436 - 446 (11page)
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초록· 키워드
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Background: The potential therapeutic values of Korean Red Ginseng extract (KRGE) in autoimmune disorders of nervous system have not been fully investigated.
Methods: We used an acute experimental autoimmune encephalomyelitis animal model of multiple sclerosis and determined the effects and mechanism of KRGE on spinal myelination.
Results: Pretreatment with KRGE (100 mg/kg, orally) for 10 days before immunization with myelin basic protein (MBP)<SUB>68-82</SUB> peptide exerted a protective effect against demyelination in the spinal cord, with inhibited recruitment and activation of immune cells including microglia, decreased mRNA expression of detrimental inflammatory mediators (interleukin-6, interferon-γ, and cyclooxygenase-2), but increased mRNA expression of protective inflammatory mediators (insulin-like growth factor β1, transforming growth factor β, and vascular endothelial growth factor-1). These results were associated with significant downregulation of p38 mitogen-activated protein kinase and nuclear factor-kB signaling pathways in microglia/macrophages, T cells, and astrocytes.
Conclusion: Our findings suggest that KRGE alleviates spinal demyelination in acute experimental autoimmune encephalomyelitis through inhibiting the activation of the p38 mitogen-activated protein kinase/nuclear factor-kB signaling pathway. Therefore, KRGE might be used as a new therapeutic for autoimmune disorders such as multiple sclerosis, although further investigation is needed.
Methods: We used an acute experimental autoimmune encephalomyelitis animal model of multiple sclerosis and determined the effects and mechanism of KRGE on spinal myelination.
Results: Pretreatment with KRGE (100 mg/kg, orally) for 10 days before immunization with myelin basic protein (MBP)<SUB>68-82</SUB> peptide exerted a protective effect against demyelination in the spinal cord, with inhibited recruitment and activation of immune cells including microglia, decreased mRNA expression of detrimental inflammatory mediators (interleukin-6, interferon-γ, and cyclooxygenase-2), but increased mRNA expression of protective inflammatory mediators (insulin-like growth factor β1, transforming growth factor β, and vascular endothelial growth factor-1). These results were associated with significant downregulation of p38 mitogen-activated protein kinase and nuclear factor-kB signaling pathways in microglia/macrophages, T cells, and astrocytes.
Conclusion: Our findings suggest that KRGE alleviates spinal demyelination in acute experimental autoimmune encephalomyelitis through inhibiting the activation of the p38 mitogen-activated protein kinase/nuclear factor-kB signaling pathway. Therefore, KRGE might be used as a new therapeutic for autoimmune disorders such as multiple sclerosis, although further investigation is needed.
목차
abstract
1. Introduction
2. Materials and methods
3. Results
4. Discussion
5. Conclusions
References
참고문헌 (54)
참고문헌 신청
[학술지(정기간행물)] - Dendrou CA / 2015 / Immunopathology of multiple sclerosis / Nat Rev 15 : 545 ~ 558
[학술지(정기간행물)] - Hoglund RA / 2014 / Multiple sclerosis and the role of immune cells / World J Exp Med 4 : 27 ~ 37
[학술지(정기간행물)] - Volpe E / 2015 / Advances in T helper 17 cell biology: pathogenic role and potential therapy in multiple sclerosis / Mediators Inflamm 2015 : 475158 ~
[학술지(정기간행물)] - Pearson G / 2001 / Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions / Endocrine Rev 22 : 153 ~ 183
[학술지(정기간행물)] - Krementsov DN / 2014 / Sexspecific control of central nervous system autoimmunity by p38 mitogenactivated protein kinase signaling in myeloid cells / Ann Neurol 75 : 50 ~ 66
[학술지(정기간행물)] - Hoglund RA / 2014 / Multiple sclerosis and the role of immune cells / World J Exp Med 4 : 27 ~ 37
[학술지(정기간행물)] - Volpe E / 2015 / Advances in T helper 17 cell biology: pathogenic role and potential therapy in multiple sclerosis / Mediators Inflamm 2015 : 475158 ~
[학술지(정기간행물)] - Pearson G / 2001 / Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions / Endocrine Rev 22 : 153 ~ 183
[학술지(정기간행물)] - Krementsov DN / 2014 / Sexspecific control of central nervous system autoimmunity by p38 mitogenactivated protein kinase signaling in myeloid cells / Ann Neurol 75 : 50 ~ 66
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