지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.12
- 수록면
- 357 - 364 (8page)
이용수
초록· 키워드
오류제보하기
Manganese (Mn) is used as main materials in various chemical processes of industry, but it suggested that Mn brings about its toxicant by fume or dust through respiratory system and skin barrier. Mn toxicant induces the loss of mental health and life quality by cerebrovascular and skin diseases. Nevertheless, it lefts much unknown on the mechanism and the effectively therapeutic methods about Mn toxicant. Therefore, this study was evaluated the cytotoxicity induced by manganese dioxide (MnO₂) in cultured NIH3T3 fibroblasts, and also, the correlation between MnO₂-induced cytotoxicity and oxidative stress was examined. While, the effect of Eclipta prostrata L. (EP) extract belong to Compositae was assessed against MnO₂-induced cytotoxicity in the view of antioxidative effect for searching the natural resources mitigating or preventing the MnO₂-induced cytotoxicity. In this study, MnO₂-induced cytotoxicity was revealed as mid-toxic by Borenfreud and Puerner`s toxic criteria, and catalase (CAT), an antioxidant prevented MnO₂-induced cytotoxicity by the remarkable increase of cell viability in these cultures. While, in the protective effect of EP extract on MnO₂-induced cytotoxicity, EP extract effectively prevented the cytotoxicity induced by MnO₂ via antioxidative effects such as xanthine oxidase (XO) inhibitory ability and DPPH-radical scavenging ability. From the above results, EP extract showed the effective prevention against MnO₂-induced cytotoxicity correlated with oxidative stress by antioxidative effects. Conclusively, this study may be useful to research or development the alternatively therapeutic agent from natural resources like EP extract for the treatment of diseases resulted in oxidative stress.
목차
서론
재료 및 방법
결과
고찰
REFERENCES
참고문헌 (48)
참고문헌 신청
[학술지(정기간행물)] - Allam JP / 2006 / The pathophysiology of atopic eczema / Clinical and Experimental Dermatology 31 : 89 ~ 93
[학술지(정기간행물)] - Berke R / 2012 / Atopic dermatitis: an overview / American Family Physician 86 : 35 ~ 42
[학술지(정기간행물)] - Bieber T / 2008 / Atopic dermatitis / The New England Journal of Medicine 358 : 1483 ~ 1494
[학술지(정기간행물)] - Brenninkmeijer EE / 2008 / Clinical differences between atopic and atopiform dermatitis / Journal of the American Academy of Dermatology 58 : 407 ~ 414
[학술지(정기간행물)] - Bunikowski R / 2001 / Effect of low-dose cyclosporin a microemulsion on disease severity, interleukin-6, interleukin-8 and tumor necrosis factor alpha production in severe pediatric atopic dermatitis / International Archives of Allergy and Immunology 125 : 344 ~ 348
[학술지(정기간행물)] - Berke R / 2012 / Atopic dermatitis: an overview / American Family Physician 86 : 35 ~ 42
[학술지(정기간행물)] - Bieber T / 2008 / Atopic dermatitis / The New England Journal of Medicine 358 : 1483 ~ 1494
[학술지(정기간행물)] - Brenninkmeijer EE / 2008 / Clinical differences between atopic and atopiform dermatitis / Journal of the American Academy of Dermatology 58 : 407 ~ 414
[학술지(정기간행물)] - Bunikowski R / 2001 / Effect of low-dose cyclosporin a microemulsion on disease severity, interleukin-6, interleukin-8 and tumor necrosis factor alpha production in severe pediatric atopic dermatitis / International Archives of Allergy and Immunology 125 : 344 ~ 348
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UCI(KEPA) : I410-ECN-0101-2019-510-000302803