Expression of Prostaglandin E2 Receptors in Acquired Middle Ear Cholesteatoma

Sujie Wang; Li Xie; Yanfei Zhang; Pengfei Xu; Aiguo Liu

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자료유형: 학술저널

저자정보: Sujie Wang Li Xie Yanfei Zhang Pengfei Xu Aiguo Liu

저널정보: 대한이비인후과학회 Clinical and Experimental Otorhinolaryngology Clinical and Experimental Otorhinolaryngology 제11권 제1호

발행연도: 2018.1

수록면: 17 - 22 (6page)

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Objectives. To investigate the expression of prostaglandin E2 receptor subtypes, E-prostanoid (EP) 1–4 receptors, in acquired cholesteatoma and its possible role in the pathologic process of this disorder. Methods. Specimens of human acquired cholesteatoma were obtained from 29 patients and 19 skin biopsies of normal external auditory canal were as controls. The mRNA and protein expression of EP receptors was assessed by quantitative real-time polymerase chain reaction, immunohistochemistry and Western blot. Results. In acquired cholesteatoma, EP1–EP4 receptors were mainly expressed on squamous epithelium and subepithelial infiltrated inflammatory cells. In external auditory canal skin, EP1–EP4 receptors were mainly expressed on squamous epithelium and glandular epithelium. The expression of EP4 receptor on mRNA and protein levels were significant lower in acquired cholesteatoma compared with controls. EP1–EP3 receptors had no significant difference between the experimental and control group. Conclusion. Low expression of EP4 may play a crucial role in the pathologic process of inflammation reaction and bone destruction in acquired cholesteatoma, but not EP1, EP2, or EP3 receptors.

참고문헌 (29)

참고문헌 신청

Olszewska E / 2004 / Etiopathogenesis of cholesteatoma / Eur Arch Otorhinolaryngol 261(1):6~24

Steven K. Juhn / 2008 / The Role of Inflammatory Mediators in the Pathogenesis of Otitis Media and Sequelae / Clinical and Experimental Otorhinolaryngology 1(3):117~138

Liu W / 2014 / Activation of the IL-6/JAK/STAT3 signaling pathway in human middle ear cholesteatoma epithelium / Int J Clin Exp Pathol 7(2):709~715

Sakuma Y / 2000 / Crucial involvement of the EP4 subtype of prostaglandin E receptor in osteoclast formation by proinflammatory cytokines and lipopolysaccharide / J Bone Miner Res 15(2):218~227

Jung TT / 1988 / Prostaglandins in human cholesteatoma and granulation tissue / Am J Otol 9(3):197~200

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