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논문 기본 정보
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- 학술저널
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- 2018.12
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Inflammation is an immune response mediated by innate immune cells of tissues, against invading microbes and cellular stress. The hallmark of inflammatory responses is the activation of inflammasomes — multiprotein oligomers comprising intracellular pattern recognition receptors and inflammatory effectors — such as ASC and pro-cysteine-aspartic protease (pro-caspase)-1. Inflammasomes can be classified as canonical or non-canonical, and their activation in response to various ligands commonly induces caspase-1 activation and gasdermin D (GSDMD) processing, leading to caspase-1-mediated maturation and secretion of the pro-inflammatory cytokines IL-1β and IL-18, and GSDMD-mediated pyroptosis through pore generation in cell membranes. Although inflammation protects the host from harmful stimuli, chronic inflammation is a critical risk factor for inflammatory diseases, and several studies have investigated the role of canonical inflammasomes in inflammatory responses and diseases, with emerging studies focusing on the role of noncanonical inflammasomes. This review discusses recent studies on the regulatory roles of the caspase-11 non-canonical inflammasome in the pathogenesis of inflammatory diseases. Additionally, it provides an insight into the development of novel therapeutics based on targeting caspase-11 non-canonical inflammasome and its downstream effectors to prevent and treat human inflammatory conditions.
목차
ABSTRACT
INTRODUCTION
CASPASE-11 NON-CANONICAL INFLAMMASOME: STRUCTURE AND ACTIVATION
ROLES OF THE CASPASE-11 NON-ANONICAL INFLAMMASOME IN INFLAMMATORY DISEASES
CONCLUSION AND PERSPECTIVES
REFERENCES
참고문헌 (76)
참고문헌 신청
[학술지(정기간행물)] - Janeway CA Jr / 2002 / Innate immune recognition / Annu Rev Immunol 20 : 197 ~ 216
[학술지(정기간행물)] - 이영수 / 2016 / Folate Receptor-Targeted Diagnostics and Therapeutics for Inflammatory Diseases / Immune Network 16 (6) : 337 ~ 343
[학술지(정기간행물)] - Takeuchi O / 2010 / Pattern recognition receptors and inflammation / Cell 140 : 805 ~ 820
[학술지(정기간행물)] - Broz P / 2016 / Inflammasomes: mechanism of assembly, regulation and signalling / Nat Rev Immunol 16 : 407 ~ 420
[학술지(정기간행물)] - Yi YS. / 2017 / Caspase-11 non-canonical inflammasome: a critical sensor of intracellular lipopolysaccharide in macrophage-mediated inflammatory responses / Immunology 152 : 207 ~ 217
[학술지(정기간행물)] - 이영수 / 2016 / Folate Receptor-Targeted Diagnostics and Therapeutics for Inflammatory Diseases / Immune Network 16 (6) : 337 ~ 343
[학술지(정기간행물)] - Takeuchi O / 2010 / Pattern recognition receptors and inflammation / Cell 140 : 805 ~ 820
[학술지(정기간행물)] - Broz P / 2016 / Inflammasomes: mechanism of assembly, regulation and signalling / Nat Rev Immunol 16 : 407 ~ 420
[학술지(정기간행물)] - Yi YS. / 2017 / Caspase-11 non-canonical inflammasome: a critical sensor of intracellular lipopolysaccharide in macrophage-mediated inflammatory responses / Immunology 152 : 207 ~ 217
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UCI(KEPA) : I410-ECN-0101-2019-517-000338102