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자료유형
학술저널
저자정보
Young-Su Yi (Kyonggi University)
저널정보
고려인삼학회 Journal of Ginseng Research Journal of Ginseng Research Vol.46 No.6
발행연도
2022.11
수록면
722 - 730 (9page)

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초록· 키워드

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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the pathogenic virus that causes coronavirus disease 2019 (COVID-19), with major symptoms including hyper-inflammation and cytokine storm, which consequently impairs the respiratory system and multiple organs, or even cause death. SARS-CoV-2 activates inflammasomes and inflammasome-mediated inflammatory signaling pathways, which are key determinants of hyperinflammation and cytokine storm in COVID-19 patients. Additionally, SARS-CoV-2 inhibits inflammasome activation to evade the host"s antiviral immunity. Therefore, regulating inflammasome initiation has received increasing attention as a preventive measure in COVID-19 patients. Ginseng and its major active constituents, ginsenosides and saponins, improve the immune system and exert anti-inflammatory effects by targeting inflammasome stimulation. Therefore, this review discussed the potential preventive and therapeutic roles of ginseng in COVID-19 based on its regulatory role in inflammasome initiation and the host"s antiviral immunity.

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ABSTRACT
1. Introduction
2. Inflammasomes
3. Regulatory roles of SARS-CoV-2 infection in inflammasome initiation
4. Inhibitory role of ginseng in inflammasome activation
5. Conclusions and perspectives: Therapeutic potential of ginseng in SARS-CoV-2 pathogenesis and COVID-19
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