지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.6
- 수록면
- 170 - 176 (7page)
이용수
초록· 키워드
오류제보하기
The objective of this study was to evaluate the characteristics of the mixtures of choline alphoscerate (alpha-glycerylphosphorylcholine, alpha-GPC), in the liquid form, and sucrose ester, which formed a solid composite. The choline alphoscerate solid composites were prepared using different ratios of sucrose ester, and different preparation methods, such as air drying and rotary evaporation, were compared for their preparation efficacy. We examined the characteristics of the solid composites by using scanning electron microscopy (SEM), angle of repose, and moisture content. The ideal mixing ratio of choline alphoscerate and sucrose ester was determined as 1:3 and air drying was found to be more suitable for the preparation of solid composites than rotary evaporation. SEM measurements of the degree of dispersion and the size of particles indicated that a high-temperature air method was more suitable. These results demonstrated the successful preparation of choline alphoscerate solid composites that have potential for industrial use.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (14)
참고문헌 신청
Barbagallo SG / 1994 / Alpha-Glycerophosphocholine in the mental recovery of cerebral ischemic attacks. An Italian multicenter clinical trial / Ann NY Acad Sci 717:253~269
Cummings JL / 1984 / Subcortical dementia: Review of an emerging concept / Arch Neurol 41:874~879
Doggrell SA / 2003 / Treatment of dementia with neurotransmission modulation / Expert Opin Investig Drugs 12:1633~1654
Fossati T / 1994 / Determination of plasma choline by high-performance liquid chromatography with a postcolumn enzyme reactor and electrochemical detection / J Chromatogr B Biomed Appl 656:59~64
Gatti G / 1992 / A comparative study of free plasma choline levels following intramuscular administration of L-α-glycerylphosphorylcholine and citicoline in normal volunteers / Int J Clin Pharmacol Ther 30:331~335
Cummings JL / 1984 / Subcortical dementia: Review of an emerging concept / Arch Neurol 41:874~879
Doggrell SA / 2003 / Treatment of dementia with neurotransmission modulation / Expert Opin Investig Drugs 12:1633~1654
Fossati T / 1994 / Determination of plasma choline by high-performance liquid chromatography with a postcolumn enzyme reactor and electrochemical detection / J Chromatogr B Biomed Appl 656:59~64
Gatti G / 1992 / A comparative study of free plasma choline levels following intramuscular administration of L-α-glycerylphosphorylcholine and citicoline in normal volunteers / Int J Clin Pharmacol Ther 30:331~335
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UCI(KEPA) : I410-ECN-0101-2019-510-000875072