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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 828 - 834 (7page)
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초록· 키워드
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Background/Aims: The renal effects of nucleos(t)ide analogs in patients with chronic hepatitis B are controversial. We aimed to compare the impact of entecavir (ETV) and tenofovir (TDF) on renal function in patients with hepatitis B virus (HBV)-related cirrhosis. Methods: We performed a retrospective cohort study of 235 consecutive treatment-naïve patients with HBV-related cirrhosis who were treated with ETV or TDF between December 2012 and November 2013 at Severance Hospital, Seoul, Korea. Results: Compensated cirrhosis was noted in 183 patients (ETV 130, TDF 53), and decompensated cirrhosis was noted in 52 patients (ETV 32, TDF 20). There were no significant changes in estimated glomerular filtration rates (eGFR) from baseline in either the ETV- or TDF-treated groups at week 96 (Chronic Kidney Disease Epidemiology Collaboration, ETV –1.68% and TDF –5.03%, p=0.358). Using a multivariate analysis, the significant factors associated with a decrease in eGFR >20% were baseline eGFR, diabetes mellitus (DM), and the use of diuretics. The use of antiviral agents and baseline decompensation were not determined to be significant factors. Conclusions: In patients with HBV-related cirrhosis, TDF has shown similar renal safety to that of ETV over a 2-year period. Renal function should be closely monitored, especially in patients who exhibit decreasing eGFR, DM, and the use of diuretics.
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참고문헌 (23)
참고문헌 신청
Ahn SH / 2016 / A 96-week randomized trial of switching to entecavir in patients who achieved virological suppression on lamivudine therapy / J Gastroenterol Hepatol 31 : 865
Barrios A / 2004 / Tenofovir-related nephrotoxicity in HIV-infected patients / AIDS 18 : 960 ~ 963
Chang TT / 2010 / Entecavir treatment for up to 5 years in patients with hepatitis B e antigen-positive chronic hepatitis B / Hepatology 51 : 422 ~ 430
Chang TT / 2010 / Long-term entecavir therapy results in the reversal of fibrosis/cirrhosis and continued histological improvement in patients with chronic hepatitis B / Hep
Combes B / 1971 / Glomerulonephritis with deposition of Australia antigen-antibody complexes in glomerular basement membrane / Lancet 2 : 234 ~ 237
Barrios A / 2004 / Tenofovir-related nephrotoxicity in HIV-infected patients / AIDS 18 : 960 ~ 963
Chang TT / 2010 / Entecavir treatment for up to 5 years in patients with hepatitis B e antigen-positive chronic hepatitis B / Hepatology 51 : 422 ~ 430
Chang TT / 2010 / Long-term entecavir therapy results in the reversal of fibrosis/cirrhosis and continued histological improvement in patients with chronic hepatitis B / Hep
Combes B / 1971 / Glomerulonephritis with deposition of Australia antigen-antibody complexes in glomerular basement membrane / Lancet 2 : 234 ~ 237
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Efficacy of prolonged entecavir monotherapy for partial virologic response to entecavir in treatment-naïve chronic hepatitis B patients
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