지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 241 - 249 (9page)
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초록· 키워드
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Background/Aims: Before tenofovir (TDF) become available in South Korea, combination therapy with entecavir (ETV) and adefovir (ADV) was the most potent regimen for chronic hepatitis B (CHB) patients who fail to respond to rescue therapy for drug resistance. We analyzed the efficacy of ETV-ADV combination therapy and investigated the clinical and clonal results of TDF-based rescue therapy in CHB patients refractory to this combination.
Methods: We retrospectively reviewed the medical records of CHB patients treated for up to 3 years with ETV-ADV combination therapy as a rescue therapy for drug resistance. In cases refractory to this combination, clinical and clonal analyses were performed for TDF-based rescue therapy.
Results: The analysis was performed on 48 patients. Twelve patients achieved a virological response (VR) within 3 years. A VR was subsequently achieved in nine of the ten patients without a VR who switched to TDF monotherapy. A VR was also achieved in six of the seven patients who switched to lamivudine-TDF combination therapy, and in two of the two patients who switched to ETV-TDF combination therapy. In an in vitro susceptibility test, viral replication was detected with TDF monotherapy but not with ETV-TDF combination therapy.
Conclusions: The efficacy of ETV-ADV combination therapy was insufficient in CHB patients who were refractory to rescue therapy. A more potent regimen such as ETV-TDF combination therapy may be considered in such refractory cases.
목차
등록된 정보가 없습니다.
참고문헌 (29)
참고문헌 신청
Ott JJ / 2012 / Global epidemiology of hepatitis B virus infection: new estimates of age-specific HBsAg seroprevalence and endemicity / Vaccine 30:2212~2219
Lai CL / 2008 / Chronic hepatitis B--new goals, new treatment / N Engl J Med 359:2488~2491
Kim JH / 2014 / Molecular diagnosis and treatment of drug-resistant hepatitis B virus / World J Gastroenterol 20:5708~5720
Sang Soo Lee / 2012 / Type and cause of liver disease in Korea: single-center experience, 2005-2010 / Clinical and Molecular Hepatology 18(3):309~315
Zoulim F / 2012 / Management of treatment failure in chronic hepatitis B / J Hepatol 56(Suppl 1):S112~S122
Lai CL / 2008 / Chronic hepatitis B--new goals, new treatment / N Engl J Med 359:2488~2491
Kim JH / 2014 / Molecular diagnosis and treatment of drug-resistant hepatitis B virus / World J Gastroenterol 20:5708~5720
Sang Soo Lee / 2012 / Type and cause of liver disease in Korea: single-center experience, 2005-2010 / Clinical and Molecular Hepatology 18(3):309~315
Zoulim F / 2012 / Management of treatment failure in chronic hepatitis B / J Hepatol 56(Suppl 1):S112~S122
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