지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Cerebral small vessel disease (SVD) is an important cause of stroke and cognitive impairment among the elderly and is a more frequent cause of stroke in Asia than in the US or Europe. Although traditional risk factors such as hypertension or diabetes mellitus are important in the development of cerebral SVD, the exact pathogenesis is still uncertain. Both, twin and family history studies suggest heritability of sporadic cerebral SVD, while the candidate gene study and the genome-wide association study (GWAS) are mainly used in genetic research. Robust associations between the candidate genes and occurrence of various features of sporadic cerebral SVD, such as lacunar infarction, intracerebral hemorrhage, or white matter hyperintensities, have not yet been elucidated. GWAS, a relatively new technique, overcomes several shortcomings of previous genetic techniques, enabling the detection of several important genetic loci associated with cerebral SVD. In addition to the more common, sporadic cerebral SVD, several single-gene disorders causing cerebral SVD have been identified. The number of reported cases is increasing as the clinical features become clear and diagnostic examinations are more readily available. These include cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy, cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy, COL4A1-related cerebral SVD, autosomal dominant retinal vasculopathy with cerebral leukodystrophy, and Fabry disease. These rare single-gene disorders are expected to play a crucial role in our understanding of cerebral SVD pathogenesis by providing animal models for the identification of cellular, molecular, and biochemical changes underlying cerebral small vessel damage.
목차
등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
Atwood LD / 2004 / Genetic variation in white matter hyperintensity volume in the Framingham Study / Stroke 35 : 1609 ~ 1613
Carmelli D / 1998 / Evidence for genetic variance in white matter hyperintensity volume in normal elderly male twins / Stroke 29 : 1177 ~ 1181
Chamorro A / 1991 / Clinical-computed tomographic correlations of lacunar infarction in the Stroke Data Bank / Stroke 22 : 175 ~ 181
Flossmann E / 2004 / Systematic review of methods and results of studies of the genetic epidemiology of ischemic stroke / Stroke 35 : 212 ~ 227
Gorelick PB / 2011 / Vascular contributions to cognitive impairment and dementia: a statement for healthcare professionals from the American heart association/American strok
Carmelli D / 1998 / Evidence for genetic variance in white matter hyperintensity volume in normal elderly male twins / Stroke 29 : 1177 ~ 1181
Chamorro A / 1991 / Clinical-computed tomographic correlations of lacunar infarction in the Stroke Data Bank / Stroke 22 : 175 ~ 181
Flossmann E / 2004 / Systematic review of methods and results of studies of the genetic epidemiology of ischemic stroke / Stroke 35 : 212 ~ 227
Gorelick PB / 2011 / Vascular contributions to cognitive impairment and dementia: a statement for healthcare professionals from the American heart association/American strok
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