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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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Background and Purpose The location of cerebral microbleeds (CMBs) may differ according to ischemic stroke subtype, and the underlying pathomechanism may differ by their location. Here, we investigated the characteristics of CMBs according to various ischemic stroke subtypes to verify this issue.
Methods Patients with acute ischemic stroke were consecutively included. The presence of CMBs was determined by gradient echo image sequence. The distribution of CMBs was classified as deep, lobar, or diffuse (both deep and lobar). The prevalence, risk factors, and distribution of CMBs were compared among patients with different stroke subtypes. Factors associated with the distribution of CMBs were investigated.
Results Among the 1033 patients included in this study, ischemic stroke subtypes were classified as large artery atherosclerosis (LAA; n=432), small vessel occlusion (SVO; n=304), and cardioembolism (CE; n=297). The prevalence of CMBs was highest in patients with SVO (40.5%), followed by CE (33.0%) and LAA (24.8%; P<0.001). The locations of CMBs was different according to subtype (P=0.004). CE [odds ratio (OR)=1.85 (1.02-3.34); P=0.042] and the use of antithrombotics [OR=1.80 (1.10-2.94); P=0.019] were associated with lobar CMBs, and old age [OR=1.02 (1.00-1.04); P=0.015] and hypertension [OR=1.61 (1.08-2.40); P=0.020] were associated with deep CMBs.
Conclusions CMBs were frequently located in the lobar area in patients with CE. Previous use of antithrombotic agents is associated with lobar CMBs. The pathogenic mechanism of CMB may differ according to ischemic stroke subtype and location.
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참고문헌 (35)
참고문헌 신청
Schrag M / 2010 / Correlation of hypointensities in susceptibility-weighted images to tissue histology in dementia patients with cerebral amyloid angiopathy : a postmortem MRI study / Acta Neuropathol 119:291~302
Wardlaw JM / 2013 / Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration / Lancet Neurol 12:822~838
Beom Joon Kim / 2013 / Cerebral Microbleeds: Their Associated Factors, Radiologic Findings, and Clinical Implications / 대한뇌졸중학회지 15(3):153~163
Bo Norrving / 2015 / Evolving Concept of Small Vessel Disease through Advanced Brain Imaging / 대한뇌졸중학회지 17(2):94~100
Poels MM / 2010 / Prevalence and risk factors of cerebral microbleeds: an update of the Rotterdam scan study / Stroke 41(10 Suppl):S103~S106
Wardlaw JM / 2013 / Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration / Lancet Neurol 12:822~838
Beom Joon Kim / 2013 / Cerebral Microbleeds: Their Associated Factors, Radiologic Findings, and Clinical Implications / 대한뇌졸중학회지 15(3):153~163
Bo Norrving / 2015 / Evolving Concept of Small Vessel Disease through Advanced Brain Imaging / 대한뇌졸중학회지 17(2):94~100
Poels MM / 2010 / Prevalence and risk factors of cerebral microbleeds: an update of the Rotterdam scan study / Stroke 41(10 Suppl):S103~S106
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