지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is inherited microangiopathy caused by mutations in the Notch3 gene. Typical findings from brain magnetic resonance imaging (MRI) include subcortical lacunes, extensive white matter change and cerebral microbleeds(CMBs). CMBs are indicative of bleeding-prone microangiopathy. Despite some studies investigating the association between lacunes and cognitive dysfunction in CADASIL, few studies have examined the relationship between cognitive dysfunction and CMBs. We sought to assess whether CMBs are associated with cognitive dysfunction in CADASIL. This study enrolled 83 consecutive patients with CADASIL between April 2012 and January 2014. Their degree of cognitive dysfunction was assessed by the Korean version of the CERAD neuropsychological assessment battery, digit span test, and the Stroop test. A 3.0-T MRI was used to obtain T1-weighted, fluid-attenuated inversion recovery, and susceptibility weighted images. In multiple logistic regression analysis, the grade of CMBs influenced tests of memory dysfunction (p=0.003). Three or more lacunes correlated with dysfunction in the executive domain (p=0.013) and attention domain (p=0.005). White matter hyperintensity (WMH) was an independent predictor of executive dysfunction (p=0.001). These findings suggest that in addition to lacunes, CMBs and WMHs may be useful imaging markers to associated with cognitive dysfunction in CADASIL.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Update on the Epidemiology, Pathogenesis, and Biomarkers of Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy
Journal of Clinical Neurology
2023 .01
-
Presentation of Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy (CADASIL) in the Acute Phase of COVID-19 Infection
Journal of Clinical Neurology
2023 .03
-
Occurrence of Intracranial Hemorrhage and Associated Risk Factors in Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy: A Systematic Review and Meta-Analysis
Journal of Clinical Neurology
2022 .09
-
High Daily Diastolic Blood Pressure Predicts Incident Stroke, Lacune, and Cerebral Microbleeds in CADASIL
대한뇌졸중학회지
2024 .01
-
Phenotypic Features of Cerebral Autosomal-Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy Subjects with R544C Mutation
Dementia and Neurocognitive Disorders(대한치매학회지)
2016 .01
-
Eighteen-Year Disease Progression and Survival in CADASIL
대한뇌졸중학회지
2021 .01
-
Prevalence and Risk Factors of Cerebral Small Vessel Disease in a Chinese Population-Based Sample
대한뇌졸중학회지
2018 .01
-
Elderly CADASIL patients with intact neurological status
대한뇌졸중학회지
2022 .09
-
Coexistence of Cerebral Microbleeds and Amyloid Pathology in Patients with Cognitive Complaints
Journal of Clinical Neurology
2020 .01
-
Characteristics of Cerebral Microbleeds
Dementia and Neurocognitive Disorders(대한치매학회지)
2018 .01
-
Prevention and Management of Cerebral Small Vessel Disease
대한뇌졸중학회지
2015 .01
-
Difference in the Location and Risk Factors of Cerebral Microbleeds According to Ischemic Stroke Subtypes
대한뇌졸중학회지
2016 .01
-
Possible Role of a Missense Mutation of p.P167S on NOTCH3 Gene Associated with Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy
Dementia and Neurocognitive Disorders(대한치매학회지)
2016 .01
-
Serum Neurofilament Light Chain Levels Are Related to Small Vessel Disease Burden
대한뇌졸중학회지
2018 .01
-
Genetics of Cerebral Small Vessel Disease
대한뇌졸중학회지
2015 .01
-
Factors Influencing Cognitive Dysfunction in Korean Patients with Rheumatoid Arthritis
노인간호학회지
2020 .01
-
Lacunar Infarction and Small Vessel Disease: Pathology and Pathophysiology
대한뇌졸중학회지
2015 .01
-
Prognostic Impact of Cerebral Small Vessel Disease on Stroke Outcome
대한뇌졸중학회지
2015 .01
-
The Prevalence and Characterization of Cerebral Microbleeds in Young People Having Intracerebral Hemorrhage
Journal of Cerebrovascular and Endovascular Neurosurgery
2018 .01
-
Diffuse cerebral microbleeds in a young adult with Down syndrome
Annals of Clinical Neurophysiology
2021 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0