지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
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초록· 키워드
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Background and Purpose Alterations in blood fatty acid (FA) composition are associated with cardiovascular diseases. We investigated whether plasma FA composition was related to stroke severity and functional outcome in acute ischemic stroke patients.
Methods We prospectively enrolled 156 patients with first-episode cerebral infarction, within 7 days of symptom onset. The proportion of FAs was analyzed using gas chromatography, and the summation of the omega-3 polyunsaturated fatty acids (ω3-PUFA), 18:3 ω3 α-linolenic acid, 20:3 ω3 eicosatrienoic acid, 20:5 ω3 eicosapentaenoic acid (EPA), and 22:6 ω3 docosahexaenoic acid (DHA) was reported as Σω3-PUFAs. Stroke severity was assessed using the National Institutes of Health Stroke Scale (NIHSS) score on admission. Poor functional outcome was defined by modified Rankin scale (mRS) ≥3 at three months after the index stroke.
Results Lower proportions of EPA (β=-0.751), DHA (β=-0.610), and Σω3-PUFAs (β=-0.462) were independently associated with higher NIHSS score, after adjusting for stroke subtype, hemoglobin, high density lipoprotein, high sensitivity C-reactive protein, fasting glucose, 16:0 palmitic acid, and Σsaturated fatty acids. Moreover, a lower proportion of DHA (odds ratio [OR]: 0.20, 95% confidence interval [CI]: 0.04-0.88), and Σω3-PUFAs (OR: 0.22, 95% CI: 0.05-0.84) showed an independent relationship with poor functional outcome after adjusting for age, sex, smoking status, NIHSS score, stroke subtype, and 16:0 palmitic acid.
Conclusions Our results demonstrate that ω3-PUFAs correlated with stroke severity on admission and functional outcomes at 3 months. ω3-PUFAs are potential blood biomarkers for prognosis of acute non-cardiogenic ischemic stroke patients.
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등록된 정보가 없습니다.
참고문헌 (21)
참고문헌 신청
/ 1991 / Beneficial effect of carotid endarterectomy in symptomatic patients with high-grade carotid stenosis. North American Symptomatic Carotid Endarterectomy Trial Collab
/ 2003 / Warfarin-Aspirin Symptomatic Intracranial Disease Trial Investigators. Design, progress and challenges of a double-blind trial of warfarin versus aspirin for sympto
Adams HP Jr / 1993 / Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treat
Calder PC / 2006 / n-3 polyunsaturated fatty acids, inflammation, and inflammatory diseases / Am J Clin Nutr 83 (Suppl 6) : 1505S ~ 1519S
Calder PC / 2012 / The role of marine omega-3 (n-3) fatty acids in inflammatory processes, atherosclerosis and plaque stability / Mol Nutr Food Res 56 : 1073 ~ 1080
/ 2003 / Warfarin-Aspirin Symptomatic Intracranial Disease Trial Investigators. Design, progress and challenges of a double-blind trial of warfarin versus aspirin for sympto
Adams HP Jr / 1993 / Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treat
Calder PC / 2006 / n-3 polyunsaturated fatty acids, inflammation, and inflammatory diseases / Am J Clin Nutr 83 (Suppl 6) : 1505S ~ 1519S
Calder PC / 2012 / The role of marine omega-3 (n-3) fatty acids in inflammatory processes, atherosclerosis and plaque stability / Mol Nutr Food Res 56 : 1073 ~ 1080
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