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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2007.1
- 수록면
- 113 - 118 (6page)
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초록· 키워드
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Treatment of oral cancers with chemotherapeutic agents
become evaluated as an effective method to reduce cancer
cell proliferation. Anti-proliferative and anti-oral cancer
activities of momordin I on oral cancer cells were evaluated
in this study. Momordin I was originally purified from a
natural product, Ampelopsis radix and showed the antiproliferative
activity against oral carcinoma, KB cells.
Obtained IC50 value was approximately 10.4 μg/ml. Timeand
dose-dependent chromosomal DNA fragmentations were
observed in momordin I-treated KB cells. Flow cytometry
analysis showed time-dependent apoptotic cell appearance
after treatment of momordin I. Approximately 18.6%
apoptotic cells were observed at 72 hours after 20 μg/ml of
momordin I treatment. These observation were consistent
with the results obtained in DNA fragmentation analysis.
These data suggest that momordin I has anti-proliferative
effect and induces cell death in KB cells through apoptosis.
목차
등록된 정보가 없습니다.
참고문헌 (24)
참고문헌 신청
Angel / 1991 / The role of Jun Fos and the AP-1 complex in cell-proliferation and transformation : 129 ~ 157
Bosmer, J / 1996 / In vitro anticancer activity of fruit extracts from vaccinium species 62 : 212 ~ 216
Han, C / 2005 / D'Ambrosio SM. Inhibition of the growth of premalignant and malignant human oral cell lines by extracts and components of black raspberries 51 : 207 ~ 217
Hyun, S.J / 1997 / Enhancement of mitogen-stimulated proliferation of low-dose radiation afapted mouse splenocytes 17 : 225 ~ 229
Kim / 1994 / Identification of active component isolated from Croton tiglium and Coptis japonica aqueous mixture and studies of its cytotoxic effect : 31 ~ 37
Bosmer, J / 1996 / In vitro anticancer activity of fruit extracts from vaccinium species 62 : 212 ~ 216
Han, C / 2005 / D'Ambrosio SM. Inhibition of the growth of premalignant and malignant human oral cell lines by extracts and components of black raspberries 51 : 207 ~ 217
Hyun, S.J / 1997 / Enhancement of mitogen-stimulated proliferation of low-dose radiation afapted mouse splenocytes 17 : 225 ~ 229
Kim / 1994 / Identification of active component isolated from Croton tiglium and Coptis japonica aqueous mixture and studies of its cytotoxic effect : 31 ~ 37
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