지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2007.1
- 수록면
- 127 - 133 (7page)
이용수
초록· 키워드
오류제보하기
Oral squamous cell carcinoma (OSCC) is the most common
malignancy and is a major cause of worldwide cancer mortality.
The proto-oncogene c-myb plays an important role in regulation
of cell growth and differentiation, and it is expressed at high
levels in hematopoietic cells and many other types of cancers.
However, the function of c-myb is not well known in OSCC.
The present study aimed to reveal the function of c-myb and to
test the alternation of cell growth and signaling by c-myb in
OSCC. In this study, c-myb and dominant-negatibe myb(DNmyb)
were expressed in an adenovirus-mediated gene delivery
system to KB cells. The over-expressed c-myb brought
increased cellular proliferation compared with control cells.
However, DN-myb infected KB cells showed significant
reduction of cell growth and enhanced induction of apoptosis to
activate PARP and caspase 9. c-myb induced increase of IGF-I,
-II and IGF-IR expressions while DN-myb down-regulated
these expression. Activation of ERK and Akt/PKB pathway
was shown only in c-myb transduced cells. These findings
suggest that the role of c-myb in cell growth of oral cancer cells
is partially mediated through the modulation of IGFs, ERK and
Akt/PKB. From this results, DN-myb is strongly recommended
as a curable gene for the treatment of c-myb dependent
malignancies such as OSCC.
목차
등록된 정보가 없습니다.
참고문헌 (21)
참고문헌 신청
Datta, K / 1995 / AH/PH domain-mediated interaction between Akt molecules and its potential role in Akt regulation 15 : 2304 ~ 2310
Guerin / 1990 / Strong association between c-myb and estrogen-receptor expression in human breast cancer : 131 ~ 135
Gupta / 1991 / Risk factors and risk markers for oral cancer in high incidence areas of the world edited by Jhonson : 29 ~ 63
Howe / 1990 / Characterization of the sequence-specific interaction of mouse c-myb protein with DNA : 161 ~ 169
Ibanez / 1990 / Trans activation of gene expression by v-myb : 2285 ~ 2293
Guerin / 1990 / Strong association between c-myb and estrogen-receptor expression in human breast cancer : 131 ~ 135
Gupta / 1991 / Risk factors and risk markers for oral cancer in high incidence areas of the world edited by Jhonson : 29 ~ 63
Howe / 1990 / Characterization of the sequence-specific interaction of mouse c-myb protein with DNA : 161 ~ 169
Ibanez / 1990 / Trans activation of gene expression by v-myb : 2285 ~ 2293
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Dominant Negative C-myb 유전자치료에 의한 두경부종양 세포의 Apoptosis 유도
대한이비인후-두경부외과학회지
2003 .01
-
Specific Expression of A-myb in Male Germ Cells
대한생식의학회 학술대회
1999 .01
-
PLAG1, SOX10, and Myb Expression in Benign and Malignant Salivary Gland Neoplasms
Journal of Pathology and Translational Medicine
2019 .01
-
Transcription Regulation Network Analysis of MCF7 Breast Cancer Cells Exposed to Estradiol
Asian Pacific journal of cancer prevention : APJCP
2012 .01
-
구강편평세포암종에서의 Cisplatin 유도 아폽토시스에서의 NF-κB의 활성화
대한구강악안면외과학회지
2006 .01
-
The Role of HS-1200 Induced Autophagy in Oral Cancer Cells
International Journal of Oral Biology
2013 .01
-
Common Docking Domain Mutation E322K of the ERK2 Gene is Infrequent in Oral Squamous Cell Carcinomas
Asian Pacific journal of cancer prevention : APJCP
2012 .01
-
Effects of FasL Expression in Oral Squamous Cell Cancer
Asian Pacific journal of cancer prevention : APJCP
2013 .01
-
Anticancer effects of genistein, green tea catechins, and cordycepin on oral squamous cell carcinoma
대한구강악안면외과학회지
2008 .01
-
The Effects of Insulin-like Growth Factor-I (IGF-I) in Mouse Lung Cancer Cells
Cancer Research and Treatment
2002 .01
-
Differences in Their Proliferation and Differentiation between B-1 and B-2 Cell
Immune Network
2006 .03
-
구강 편평세포암종에서의 암줄기세포 이론과 최신 지견
대한구강악안면외과학회지
2011 .01
-
Cancer Stem Cells and Stemness Markers in Oral Squamous Cell Carcinomas
Asian Pacific journal of cancer prevention : APJCP
2014 .01
-
Roles of Human Papillomaviruses and p16 in Oral Cancer
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Role of proteases, cytokines, and growth factors in bone invasion by oral squamous cell carcinoma
International Journal of Oral Biology
2019 .01
-
Lipopeptides Extract from Bacillus Amyloliquefaciens Induce Human Oral Squamous Cancer Cell Death
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Effect of β-carotene on Cell Growth Inhibition of KB Human Oral Cancer Cells
International Journal of Oral Biology
2016 .01
-
Serum Level of Mast Cell Tryptase in Patients with Oral Squamous Cell Carcinoma: Lack of Correlation with Clinicopathologic Factors
Asian Pacific journal of cancer prevention : APJCP
2013 .01
-
Assessment of Cellular Proliferation in Oral Verrucous Carcinoma and Well-Differentiated Oral Squamous Cell Carcinoma Using Ki67: A Non-Reliable Factor for Differential Diagnosis?
Asian Pacific journal of cancer prevention : APJCP
2012 .01
-
Simvastatin Induces Apoptosis and Suppresses Insulin-Like Growth Factor 1 Receptor in Bile Duct Cancer Cells
Gut and Liver
2016 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0