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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 162 - 169 (8page)
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초록· 키워드
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Background and Purpose The outcome for older stroke patients who undergo endovascular revascularization remains unsatisfactory. We aimed to determine the effect of the extent of baseline ischemia on outcome according to age, testing the hypothesis that the restorative capacity for recovery is only marginal in older patients.
Methods Two hundred and thirteen patients who underwent endovascular revascularization due to occlusion in the M1 segment of the middle cerebral artery (with or without internal carotid artery occlusions) were selected for analysis. Patients were categorized into three age groups: group A (<66 years), group B (66–75 years), and group C (>75 years). Using pretreatment diffusion-weighted imaging (DWI), the Alberta Stroke Program Early CT Score (ASPECTS) and lesion volume were independently measured and analyzed in relation to a favorable outcome.
Results A favorable outcome was achieved in 111 of 213 patients overall: in 60 of the 94 (63.8%) patients in group A, in 36 of the 70 (51.4%) patients in group B, and in 15 of the 49 (30.6%) patients in group C (p=0.001). In older stroke patients (group C), a DWI ASPECTS ≥9 and lesion volume ≤5 mL were found to predict a favorable outcome, which was more restrictive than the cutoffs for their younger counterparts (groups A and B; DWI ASPECTS ≥8 and lesion volume ≤20 mL).
Conclusions The age-adjusted pretreatment DWI lesion volume and ASPECTS may represent useful surrogate markers for functional outcome according to age. The use of more-restrictive inclusion criteria for older stroke patients could be warranted, although larger studies are necessary to confirm these findings.
목차
등록된 정보가 없습니다.
참고문헌 (23)
참고문헌 신청
Berkhemer OA / 2015 / A randomized trial of intraarterial treatment for acute ischemic stroke / N Engl J Med 372 : 11 ~ 20
Campbell BC / 2015 / Endovascular therapy for ischemic stroke with perfusionimaging selection / N Engl J Med 372 : 1009 ~ 1018
Chandra RV / 2012 / Elderly patients are at higher risk for poor outcomes after intra-arterial therapy / Stroke 43 : 2356 ~ 2361
Goyal M / 2015 / Randomized assessment of rapid endovascular treatment of ischemic stroke / N Engl J Med 372 : 1019 ~ 1030
Higashida RT / 2003 / Trial design and reporting standards for intra-arterial cerebral thrombolysis for acute ischemic stroke / Stroke 34 : e109
Campbell BC / 2015 / Endovascular therapy for ischemic stroke with perfusionimaging selection / N Engl J Med 372 : 1009 ~ 1018
Chandra RV / 2012 / Elderly patients are at higher risk for poor outcomes after intra-arterial therapy / Stroke 43 : 2356 ~ 2361
Goyal M / 2015 / Randomized assessment of rapid endovascular treatment of ischemic stroke / N Engl J Med 372 : 1019 ~ 1030
Higashida RT / 2003 / Trial design and reporting standards for intra-arterial cerebral thrombolysis for acute ischemic stroke / Stroke 34 : e109
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