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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2008.1
- 수록면
- 99 - 106 (8page)
이용수
초록· 키워드
오류제보하기
Antiepileptic drugs (AEDs) can adversely affect cognitive function by suppressing neuronal
excitability or enhancing inhibitory neurotransmission. The main cognitive effects of AEDs are
impaired attention, vigilance, and psychomotor speed, but secondary effects can manifest on
other cognitive functions. Although the long-term use of AEDs can obviously elicit cognitive
dysfunction in epilepsy patients, their cognitive effects over short periods of up to a year are inconclusive
due to methodological problems. In general, the effects on cognition are worse for
older AEDs (e.g., phenobarbital) than for placebo, nondrug condition, and newer AEDs. However,
topiramate is the newer AED that has the greatest risk cognitive impairment irrespective of the
comparator group. Since the cognitive impact of AEDs can be serious, clinicians should be
alert to adverse events by evaluating cognitive function using screening tests. Adverse cognitive
events of AEDs can be avoided by slow titration to the lowest effective dosage and by
avoiding polytherapy.
목차
등록된 정보가 없습니다.
참고문헌 (25)
참고문헌 신청
Aldenkamp AP / 2002 / Randomized double-blind parallel-group study comparing cognitive effects of a low-dose lamotrigine with valproate and placebo in healthy volunteers / E
Aldenkamp AP / 2003 / antiepileptic drugs and cognitive issues / Epilepsia 44 : S21 ~ S29
Bourgeois BF / 2004 / Determining the effects of antiepileptic drugs on cognitive function in pediatric patients with epilepsy / J Child Neurol 19 : S15 ~ S24
Carpay JA / 2005 / Complaints associatedwith the use of antiepileptic drugs: results from a community-based study / Seizure 14 : 198 ~ 206
Chadwick DW / 1998 / A double-blind trial of gabapentin monotherapy for newly diagnosed partial seizures. International Gabapentin Monotherapy Study Group 945-77 / Neurology
Aldenkamp AP / 2003 / antiepileptic drugs and cognitive issues / Epilepsia 44 : S21 ~ S29
Bourgeois BF / 2004 / Determining the effects of antiepileptic drugs on cognitive function in pediatric patients with epilepsy / J Child Neurol 19 : S15 ~ S24
Carpay JA / 2005 / Complaints associatedwith the use of antiepileptic drugs: results from a community-based study / Seizure 14 : 198 ~ 206
Chadwick DW / 1998 / A double-blind trial of gabapentin monotherapy for newly diagnosed partial seizures. International Gabapentin Monotherapy Study Group 945-77 / Neurology
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