지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
초록· 키워드
오류제보하기
Objectives：Several studies suggested that cytokines could be involved in the pathogenesis of mood disorders, while data
for bipolar disorder is relatively deficient (BD). BD, Knowned to have a inherited tendency, has been considered to be
related with T-helper cell system. This study was designed to investigate the association between polymorphism of monocyte
chemoattractant protein-1 (MCP1) gene at promoter -2518 and BD.
Methods：Patients with BD (n=92) in accordance with DSM-IV criteria and control subjects (n=114) participated in this
study. DNA was extracted from whole blood and the MCP-1 gene promoter region was amplified by polymerase chain
reaction-based method.
Results：Genotype and allele distributions in patients with BD were not different from those of control subjects (p=0.587；
p=0.384). Genotype and allele distributions in accordance to presence or absence of suicide attempt (p=0.423), family history
(p=0.733) and psychotic feature (p=0.436) were not different between the two groups.
Conclusion：Present study suggests that the MCP1 promoter -2518 polymorphism may not affect the susceptibility and
clinical diversity of the development of BD. (J Korean Neuropsychiatr Assoc 2004;43(5):524-528)
목차
등록된 정보가 없습니다.
참고문헌 (26)
참고문헌 신청
/ 1967 / Development of a rating scale for primary depressiveillness 6 : 278 ~ 296
/ 1976 / ECDEU Assessment Manual for Psychopharmacology US Department of Health : 223 ~ 244
/ 1978 / A rating scale formania:reliability,validity and sensitivity 133 : 429 ~ 435
/ 1994 / Cytokine-specific central monoamine alterationsinduced by interleukin-1,-2 and -6 643 : 40 ~ 49
/ 1995 / Interleukin-2and interleukin-6 in schizophrenia and mania:effects of neurolepticsand mood stabilizers 29 : 141 ~ 152
/ 1976 / ECDEU Assessment Manual for Psychopharmacology US Department of Health : 223 ~ 244
/ 1978 / A rating scale formania:reliability,validity and sensitivity 133 : 429 ~ 435
/ 1994 / Cytokine-specific central monoamine alterationsinduced by interleukin-1,-2 and -6 643 : 40 ~ 49
/ 1995 / Interleukin-2and interleukin-6 in schizophrenia and mania:effects of neurolepticsand mood stabilizers 29 : 141 ~ 152
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