지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2007.9
- 수록면
- 183 - 187 (5page)
이용수
초록· 키워드
오류제보하기
Monocyte chemoattractant protein-1 (MCP-1) and interleukin-8 (IL-8) play a key role in development of atherosclerosis. To take into account the atherogenic properties of MCP-1 and IL-8 and its influence on insulin resistance, we examined circulating levels of MCP-1 and IL-8 in adults. We recruited 292 subjects (84 males and 208 females) aged between 29 and 79 years. MCP-1 and IL-8 levels were measured by enzyme-linked immunosorbent assay. Age, total cholesterol, HDL-cholesterol, and LDL-cholesterol levels were significantly higher in female subjects (P＜0.01, respectively), but diastolic blood pressure (BP) was significantly lower in female subjects compared to male subjects. MCP-1 and IL-8 levels were tended to increase with age, the highest in their seventies. MCP-1 (P=0.05) and IL-8 (P＜0.01) levels were higher in males than in females. MCP-1 was positively correlated with age (r=0.17, P＜0.05), IL-8 (r=0.26, P＜0.01), fasting insulin (r=0.30, P＜0.01), and HOMA-IR (r=0.29, P＜0.01). In linear regression analysis, age was found to be independent factor associated with MCP-1 adjusted by age, BMI, fasting glucose, triglyceride, and systolic BP. In conclusion, age was found to be independent factor associated with MCP-1. It is possible that an increase of MCP-1 in adults with age may be risk to atherosclerosis and diabetic properties.
목차
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (26)
참고문헌 신청
1. [학술지(정기간행물)] - Berrahmoune, H / 2006 / Biological determinants of and reference values for plasma interleukin-8, monocyte chemoattractant protein-1, epidermal growth factor, and vascular endothelial growth factor: Results from the STANISLAS cohort / Clin Chem. 52 : 504 ~ 510
2. [학술지(정기간행물)] - Bruun, JM / 2003 / Association between measures of insulin sensitivity and circulating levels of interleukin-8, interleukin-6 and tumor necrosis factor-alpha. Effect of weight loss in obese men / Eur J Endocrinol. 148 : 535 ~ 542
3. [학술지(정기간행물)] - de Lemos, JA / 2003 / Association between plasma levels of monocyte chemoattractant protein-1 and long-term clinical outcomes in patients with acute coronary syndromes / Circulation 107 : 690 ~ 695
4. [학술지(정기간행물)] - Deo, R / 2004 / Association among plasma levels of monocyte chemoattractant protein-1, traditional cardiovascular risk factors, and subclinical atherosclerosis / J Am Coll Cardiol. 444 : 1812 ~ 1818
5. [학술지(정기간행물)] - Friedewald, WT / 1972 / Fridrikson DS: Estimation of concentrations of low density lipoprotein cholesterol in plasma without use of preparative ultracentrifuge / Clin Chem. 18 : 499 ~ 502
2. [학술지(정기간행물)] - Bruun, JM / 2003 / Association between measures of insulin sensitivity and circulating levels of interleukin-8, interleukin-6 and tumor necrosis factor-alpha. Effect of weight loss in obese men / Eur J Endocrinol. 148 : 535 ~ 542
3. [학술지(정기간행물)] - de Lemos, JA / 2003 / Association between plasma levels of monocyte chemoattractant protein-1 and long-term clinical outcomes in patients with acute coronary syndromes / Circulation 107 : 690 ~ 695
4. [학술지(정기간행물)] - Deo, R / 2004 / Association among plasma levels of monocyte chemoattractant protein-1, traditional cardiovascular risk factors, and subclinical atherosclerosis / J Am Coll Cardiol. 444 : 1812 ~ 1818
5. [학술지(정기간행물)] - Friedewald, WT / 1972 / Fridrikson DS: Estimation of concentrations of low density lipoprotein cholesterol in plasma without use of preparative ultracentrifuge / Clin Chem. 18 : 499 ~ 502
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UCI(KEPA) : I410-ECN-0101-2009-510-015971284