Decreased Serum Monocyte Chemoattractant Protein-1 in Salivary Gland Tumor Patients

Mardani, Maryam; Andisheh-Tadbir, Azadeh; Khademi, Bijan; Melekzadeh, Mahyar; Vaziri, Lida

추천

검색

자료유형: 학술저널

저자정보: Mardani, Maryam (Department of Oral Medicine, School of Dentistry, Shiraz University of Medical Sciences) Andisheh-Tadbir, Azadeh (Prevention of Oral and Dental Disease Research Center, School of Dentistry, Shiraz University of Medical Sciences) Khademi, Bijan (Shiraz Institute for Cancer Research, Shiraz University of Medical Sciences) Melekzadeh, Mahyar (Shiraz Institute for Cancer Research, Shiraz University of Medical Sciences) Vaziri, Lida (Undergraduate Student, School of Dentistry Shiraz University of Medical Sciences)

저널정보: 아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제17권 제7호

발행연도: 2016.1

수록면: 3,601 - 3,604 (4page)

이용수

📌

연구주제

📖

연구배경

🔬

연구방법

🏆

연구결과

초록· 키워드

오류제보하기

Background: The monocyte chemoattractant protein-1 (MCP-1/CCL2) is a potent chemoattractant for natural killer cells, monocytes, and memory T lymphocytes. However, any role in the genesis of salivary gland tumors (SGT) is unknown. To assess the diagnostic relevance of chemokines in SGT, MCP-1 levels in the serum of patients were investigated in association with tumor progression and clinical aggressiveness. Materials and Methods: Using an ELISA kit, we assessed and compared the circulating levels of MCP-1 in blood serum of 70 SGT patients with 44 healthy control samples. Results: The results of this study showed that the concentration of MCP-1 was significantly lower in patients with benign ($463.8{\pm}158.5pg/ml$, P=0.033) and malignant ($454.8{\pm}190.4pg/ml$, P=0.007) SGT than in healthy subjects ($645.7{\pm}338.9$). No significant difference in mean serum levels of MCP-1 was observed between the benign and malignant group (p=0.9). While MCP-1 levels were lower in patients with an advanced clinical stage, advanced tumor size, higher tumor grade, or lymph node involvement, but the mean MCP-1 level between groups showed no statistically significant difference (p>0.05). Conclusions: MCP-1 levels in the serum of patients with SGT were decreased, indicating that this might a good marker for discriminating patients with SGT from healthy people. However, no clear-cut relationship was detected between MCP-1 levels and clinicopathologic factors, and MCP-1 is not a good marker for evaluating tumor dissemination.

#Salivary gland tumor #MCP-1 #pleomorphic adenoma #adenoid cystic carcinoma #mucoepidermoid

참고문헌 (0)

참고문헌 신청

참고문헌이 DBpia에서 서비스 중이라면, [참고문헌 신청]을 통해 등록해보세요

함께 읽어보면 좋을 논문

논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!