지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 511 - 517 (7page)
이용수
초록· 키워드
오류제보하기
ObjectiveaaThe structural alteration of brain shown in patients with alcohol use disorder (AUD) can originate from both alcohol effects and genetic or developmental processes. We compared surface-based parameters of patients with AUD with healthy controls to prove the applicability of surface-based morphometry with head size correction and to determine the areas that were sensitive to brain alteration related to AUD.
MethodsaaTwenty-six abstinent male patients with AUD (alcohol group, mean abstinence=13.2 months) and twenty-eight age-matched healthy participants (control group) were recruited from an inpatient mental hospital and community. All participants underwent a 3T MRI scan. Surface-based parameters were determined by using FreeSurfer.
ResultsaaEvery surface-based parameter of the alcohol group was lower than the corresponding control group parameter. There were large group differences in the whole brain, grey and white matter volume, and the differences were more prominent after head size correction. Significant group differences were shown in cortical thicknesses in entire brain regions, especially in parietal, temporal and frontal areas. There were no significant group differences in surface areas, but group difference trends in surface areas of the frontal and parietal cortices were shown after head size correction.
ConclusionaaMost of the surface-based parameters in alcohol group were altered because of incomplete recovery from chronic alcohol exposure and possibly genetic or developmental factors underlying the risk of AUD. Surface-based morphometry with controlling for head size is useful in comparing the volumetric parameters and the surface area to a lesser extent in alcohol-related brain alteration.
목차
등록된 정보가 없습니다.
참고문헌 (34)
참고문헌 신청
Zahr NM / 2011 / Clinical and pathological features of alcohol-related brain damage / Nat Rev Neurol 7:284~294
Sullivan EV / 2005 / Neurocircuitry in alcoholism : a substrate of disruption and repair / Psychopharmacology 180:583~594
Bühler M / 2011 / Alcohol and the human brain : a systematic review of different neuroimaging methods / Alcohol Clin Exp Res 35:1771~1793
Benegal V / 2007 / Gray matter volume abnormalities and externalizing symptoms in subjects at high risk for alcohol dependence / Addict Biol 12:122~132
Pitel AL / 2011 / Signs of preclinical Wernicke’s encephalopathy and thiamine levels as predictors of neuropsychological deficits in alcoholism without Korsakoff’s syndrome / Neuropsychopharmacology 36:580~588
Sullivan EV / 2005 / Neurocircuitry in alcoholism : a substrate of disruption and repair / Psychopharmacology 180:583~594
Bühler M / 2011 / Alcohol and the human brain : a systematic review of different neuroimaging methods / Alcohol Clin Exp Res 35:1771~1793
Benegal V / 2007 / Gray matter volume abnormalities and externalizing symptoms in subjects at high risk for alcohol dependence / Addict Biol 12:122~132
Pitel AL / 2011 / Signs of preclinical Wernicke’s encephalopathy and thiamine levels as predictors of neuropsychological deficits in alcoholism without Korsakoff’s syndrome / Neuropsychopharmacology 36:580~588
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