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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한정신약물학회 Clinical Psychopharmacology and Neuroscience Clinical Psychopharmacology and Neuroscience 제16권 제3호
- 발행연도
- 2018.1
- 수록면
- 290 - 301 (12page)
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초록· 키워드
오류제보하기
Objective: Baclofen is a promising treatment for alcohol use disorders (AUD), although its clinical response in humans is mixed. The present study aimed at investigating the impact of baclofen treatment on cue-induced brain activation pattern and its relationship with relapse outcomes. Methods: Twenty-three inpatients with AUD underwent a functional magnetic resonance imaging cue-reactivity task before beginning medication with baclofen and 2 weeks later. Twelve additional inpatients with AUD, who did not receive any anticraving medications, formed the control group. All subjects were prospectively followed up for 90 days post-discharge or until lapse to first alcohol use. Results: Whole-brain linear mixed effects analysis revealed a significant group-by-time interaction with greater activation of the bilateral dorsolateral pre-frontal cortex and right anterior cingulate cortex (ACC) following baclofen treatment in comparison with the control group. Further, cox regression analysis revealed that increased activation of ACC and deactivation of insular cortex (IC) was associated with longer time to first alcohol use only in the baclofen treatment group but not in the control group. Conclusion: This study provides preliminary evidence for the neural predictors of baclofen treatment response in AUD. Baclofen treatment in AUD was associated with changes in cue-reactivity at critical brain regions within the incentive- salience network. Importantly, baclofen treatment-related specific activation of regions involved in cognitive control (ACC) and deactivation of regions involved in reward anticipation (IC) prolonged the time to first alcohol drink
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등록된 정보가 없습니다.
참고문헌 (62)
참고문헌 신청
McLellan AT / 2000 / Drug dependence, a chronic medical illness: implications for treatment, insurance, and outcomes evaluation / JAMA 284:1689~1695
World Health Organization / 2014 / Global status report on alcohol and health 2014
Swift RM / 1999 / Drug therapy for alcohol dependence / N Engl J Med 340:1482~1490
Zindel LR / 2014 / Pharmacotherapy of alcohol use disorders: seventy-five years of progress / J Stud Alcohol Drugs Suppl 75(Suppl 17):79~88
Soyka M / 2014 / Nalmefene for the treatment of alcohol dependence: a current update / Int J Neuropsychopharmacol 17:675~684
World Health Organization / 2014 / Global status report on alcohol and health 2014
Swift RM / 1999 / Drug therapy for alcohol dependence / N Engl J Med 340:1482~1490
Zindel LR / 2014 / Pharmacotherapy of alcohol use disorders: seventy-five years of progress / J Stud Alcohol Drugs Suppl 75(Suppl 17):79~88
Soyka M / 2014 / Nalmefene for the treatment of alcohol dependence: a current update / Int J Neuropsychopharmacol 17:675~684
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