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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 531 - 537 (7page)
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초록· 키워드
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Objective The aim of this study was to examine the change in the hippocampal volume and shape in early-onset mild cognitive impairment (EO-MCI) associated with the APOE ε4 carrier state. Methods This study had 50 subjects aged 55–63 years, all of whom were diagnosed with MCI at baseline via the Korean version of the Consortium to Establish a Registry for Alzheimer’s Disease Assessment Packet. The EO-MCI patients were divided into the MCI continued (MCIcont) and Alzheimer’s disease (AD) converted (ADconv) groups 2 years later. The hippocampal volume and shape were measured for all the subjects. The local shape analysis (LSA) was used to conduct based on the 2-year-interval magnetic resonance imaging scans. Results There was a significant correlation between APOE ε4 allele and hippocampal volume atrophy. Over two years, the volume reduction in the left hippocampus was found to be faster than that in the right hippocampus, especially in the APOE ε4 carriers. LSA showed that the 2 subfields were significantly affected in the left hippocampus. Conclusion These results suggest that the possession of APOE ε4 allele may lead to greater predilection for left hippocampal atrophy in EO-MCI, and some specific subfields of the hippocampus may be more prominently involved.
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등록된 정보가 없습니다.
참고문헌 (40)
참고문헌 신청
Farias ST / 2009 / Progression of mild cognitive impairment to dementia in clinic- vs community-based cohorts / Arch Neurol 66:1151~1157
Petersen RC / 2009 / Mild cognitive impairment: ten years later / Arch Neurol 66:1447~1455
Apostolova LG / 2006 / Conversion of mild cognitive impairment to Alzheimer disease predicted by hippocampal atrophy maps / Arch Neurol 63:693~699
Apostolova LG / 2010 / 3D comparison of low, intermediate, and advanced hippocampal atrophy in MCI / Hum Brain Mapp 31:786~797
Killiany RJ / 2000 / Use of structural magnetic resonance imaging to predict who will get Alzheimer's disease / Ann Neurol 47:430~439
Petersen RC / 2009 / Mild cognitive impairment: ten years later / Arch Neurol 66:1447~1455
Apostolova LG / 2006 / Conversion of mild cognitive impairment to Alzheimer disease predicted by hippocampal atrophy maps / Arch Neurol 63:693~699
Apostolova LG / 2010 / 3D comparison of low, intermediate, and advanced hippocampal atrophy in MCI / Hum Brain Mapp 31:786~797
Killiany RJ / 2000 / Use of structural magnetic resonance imaging to predict who will get Alzheimer's disease / Ann Neurol 47:430~439
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