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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2004.1
- 수록면
- 43 - 49 (7page)
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PURPOSE: Adriamycin is one of the most commonly used drugs in the treatment of breast cancer. This study was performed to understand the molecular mechanisms of drug resistance in breast cancer cells. MATERIALS AND METHODS: We have analyzed the MCF-7 breast cell line and its adriamycin-resistant variants, MCF-7/ADR using human 10 K element cDNA microarrays. RESULTS: We defined 68 genes that were up-regulated (14 genes) or down-regulated (54 genes) in adriamycin resistant breast cancer cells. Several genes, such as G protein-coupled receptor kinase 5, phospholipase A2, guanylate cyclase 1, vimentin, matrix metalloproteinase 1 are up-regulated in drug resistant cells. Several genes, such as interferon, alpha-inducible protein 27, forkhead box M1, mitogen-activated protein kinase 6, regulator of mitotic spindle assembly 1 and tumor necrosis factor superfamily are down-regulated in adriamycin resistant cells. The altered expression of genes observed in microarray was verified by RT-PCR. CONCLUSION: These findings show that cDNA microarray analysis can be used to obtain gene expression profiles reflecting the effect of anticancer drugs on breast cancer cells. Such data may lead to the assigning of signature expression profiles of drug-resistant tumors which may help predict responses to drugs and assist in the design of tailored therapeutic regimens to overcome drug resistance.(Cancer Res Treat. 2004;36:43-49)
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참고문헌 (25)
참고문헌 신청
/ / Capaldi RA. Structure and function of cytochrome c oxidase.Annu Rev Biochem 1990 : 569 ~ 596
/ / Coon JS. Relationship of theexpression of the multidrug resistance gene product in human colon carcinoma to local tumor aggressivenessand lymph node metastasis. Cancer R
/ / Merle P. Separationof mammalian cytochrome c oxidase into 13 polypeptides bya sodium dodecyl sulfate-gel electrophoretic procedure. AnalBiochem 1983 : 517 ~ 521
/ / Myers CE. Adriamycinactivation and oxygen free radical formation in humanbreast tumor cells protective role of glutathione peroxidase inadriamycin resistance. Cancer Res
/ 1988 / Molecular and cellular biology of intermediate filaments. 57 : 593 ~ 625
/ / Coon JS. Relationship of theexpression of the multidrug resistance gene product in human colon carcinoma to local tumor aggressivenessand lymph node metastasis. Cancer R
/ / Merle P. Separationof mammalian cytochrome c oxidase into 13 polypeptides bya sodium dodecyl sulfate-gel electrophoretic procedure. AnalBiochem 1983 : 517 ~ 521
/ / Myers CE. Adriamycinactivation and oxygen free radical formation in humanbreast tumor cells protective role of glutathione peroxidase inadriamycin resistance. Cancer Res
/ 1988 / Molecular and cellular biology of intermediate filaments. 57 : 593 ~ 625
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