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자료유형
학술저널
저자정보
저널정보
대한암학회 Cancer Research and Treatment Cancer Research and Treatment 제47권 제2호
발행연도
2015.1
수록면
290 - 297 (8page)

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Purpose The aim of this study is to evaluate the safety of fertility-sparing surgery as the treatmentfor patients with primary mucinous epithelial ovarian cancer. Materials and MethodsA retrospective study of patients with mucinous ovarian cancer between 1991 and 2010was performed. The demographics and survival outcomes were compared between patientswho underwent fertility-sparing surgery and those who underwent radical surgery. ResultsA total of 110 patients underwent primary surgery. At the time of surgery, tumors appearedto be grossly confined to the ovaries in 90 patients, and evidence of metastasis was definitein 20 patients. Of the 90 patients with tumors that appeared to be grossly confined to theovaries at surgical exploration, 35 (38.9%) underwent fertility-sparing surgery. The Kaplan-Meier curve and the log rank test showed no difference in either recurrence-free survival(p=0.792) or disease-specific survival (p=0.706) between the two groups. Furthermore,there was no significant difference in recurrence-free survival (p=0.126) or disease-specificsurvival (p=0.377) between the two groups, even when the analysis was limited to womenbelow the age of 40. In a multivariate Cox model, fertility-sparing surgery had no effect oneither recurrence-free survival (recurrence hazard ratio [HR], 1.20; 95% confidence interval[CI], 0.25 to 5.71) or disease-specific survival (death HR, 0.88; 95% CI, 0.17 to 4.60). ConclusionFertility-sparing surgery in primary mucinous cancer grossly confined to the ovaries may bea safe option and one not associated with an increase in recurrence or mortality.

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