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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 398 - 402 (5page)
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초록· 키워드
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Anaplastic lymphoma kinase (ALK) fusion is a common mechanism underlying patho- genesis of non-small cell lung carcinoma (NSCLC) where these rearrangements represent important diagnostic and therapeutic targets. In this study, we found a new ALK fusion gene, SEC31A-ALK, in lung carcinoma from a 53-year-old Korean man. The conjoined region in the fusion transcript was generated by the fusion of SEC31A exon 21 and ALK exon 20 by genomic rearrangement, which contributed to genera- tion of an intact, in-frame open reading frame. SEC31A-ALK encodes a predicted fusion protein of 1,438 amino acids comprising the WD40 domain of SEC31A at the N-terminus and ALK kinase domain at the C-terminus. Fluorescence in situ hybridiza- tion studies suggested that SEC31A-ALK was generated by an unbalanced genomic rearrangement associated with loss of the 3!-end of SEC31A. This is the first report of SEC31A-ALK fusion transcript in clinical NSCLC, which could be a novel diagnostic and therapeutic target for patients with NSCLC.
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참고문헌 (15)
참고문헌 신청
Ardini E / 2010 / Anaplastic lymphoma kinase : role in specific tumours, and development of small molecule inhibitors for cancer therapy / Cancer Lett 299:81~94
Webb TR / 2009 / Anaplastic lymphoma kinase : role in cancer pathogenesis and small-molecule inhibitor development for therapy / Expert Rev Anticancer Ther 9:331~356
Drexler HG / 2000 / Pathobiology of NPM-ALK and variant fusion genes in anaplastic large cell lymphoma and other lymphomas / Leukemia 14:1533~1559
Soda M / 2007 / Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer / Nature 448:561~566
Hong M / 2014 / HIP1-ALK, a novel fusion protein identified in lung adenocarcinoma / J Thorac Oncol 9:419~422
Webb TR / 2009 / Anaplastic lymphoma kinase : role in cancer pathogenesis and small-molecule inhibitor development for therapy / Expert Rev Anticancer Ther 9:331~356
Drexler HG / 2000 / Pathobiology of NPM-ALK and variant fusion genes in anaplastic large cell lymphoma and other lymphomas / Leukemia 14:1533~1559
Soda M / 2007 / Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer / Nature 448:561~566
Hong M / 2014 / HIP1-ALK, a novel fusion protein identified in lung adenocarcinoma / J Thorac Oncol 9:419~422
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