지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.1
- 수록면
- 601 - 606 (6page)
이용수
초록· 키워드
오류제보하기
A 61-year-old male patient was simultaneously diagnosed with lung adenocarcinoma and inflammatory myofibroblastic tumor (IMT). The lung adenocarcinoma and IMT harbored two distinct types of ALK translocation, LOC101927285-ALK, and TPM3-ALK, respectively. The ALK Ventana showed strong positivity on both lesions. The patient was therefore given an endobronchial cryotherapy and ALK inhibitor crizotinib. The tumors showed durable response however the left lung adenocarcinoma relapsed at 17th month post-crizotinib treatment. Tissue re-biopsy on the resistant tumor revealed an ALK exon 23 C1156Y missense mutation in addition to LOC101927285-ALK mutation. Further RNA-based sequence uncovered that the noncoding region rearrangement is the fusion mutation of EML4-ALK. The patient was therefore received alectinib, and the tumor exhibited partly response. Overall, it is very rare that two types of pulmonary tumors exist in one patient driven by two distinct ALK fusions, which emphasizes the necessity of gene sequencing in clinical decision-making and individualized therapy.
목차
등록된 정보가 없습니다.
참고문헌 (8)
참고문헌 신청
Shackelford RE / 2014 / ALK-rearrangements and testing methods in non-small cell lung cancer : a review / Genes Cancer 5:1~14
Butrynski JE / 2010 / Crizotinib in ALK-rearranged inflammatory myofibroblastic tumor / N Engl J Med 363:1727~1733
Montgomery EA / 2006 / Inflammatory myofibroblastic tumors of the urinary tract : a clinicopathologic study of 46cases, including a malignant example inflammatory fibrosarcoma and a subset associated with high-grade urothelial carcinoma / Am J Surg Pathol 30:1502~1512
Mansfield AS / 2016 / Chromoplectic TPM3-ALK rearrangement in a patient with inflammatory myofibroblastic tumor who responded to ceritinib after progression on crizotinib / Ann Oncol 27:2111~2117
Kazandjian D / 2014 / FDA approval summary : crizotinib for the treatment of metastatic non-small cell lung cancer with anaplastic lymphoma kinase rearrangements / Oncologist 19:e5~11
Butrynski JE / 2010 / Crizotinib in ALK-rearranged inflammatory myofibroblastic tumor / N Engl J Med 363:1727~1733
Montgomery EA / 2006 / Inflammatory myofibroblastic tumors of the urinary tract : a clinicopathologic study of 46cases, including a malignant example inflammatory fibrosarcoma and a subset associated with high-grade urothelial carcinoma / Am J Surg Pathol 30:1502~1512
Mansfield AS / 2016 / Chromoplectic TPM3-ALK rearrangement in a patient with inflammatory myofibroblastic tumor who responded to ceritinib after progression on crizotinib / Ann Oncol 27:2111~2117
Kazandjian D / 2014 / FDA approval summary : crizotinib for the treatment of metastatic non-small cell lung cancer with anaplastic lymphoma kinase rearrangements / Oncologist 19:e5~11
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Analysis of Histologic Features Suspecting Anaplastic Lymphoma Kinase (ALK)-Expressing Pulmonary Adenocarcinoma
Journal of Pathology and Translational Medicine
2015 .01
-
Clinicopathological Study of 18 Cases of Inflammatory Myofibroblastic Tumors with Reference to ALK-1 Expression: 5-Year Experience in a Tertiary Care Center
Journal of Pathology and Translational Medicine
2017 .01
-
Characteristics of Renal Cell Carcinoma Harboring TPM3-ALK Fusion
Yonsei Medical Journal
2020 .01
-
Alterations in PD-L1 Expression Associated with Acquisition of Resistance to ALK Inhibitors in ALK-Rearranged Lung Cancer
Cancer Research and Treatment
2019 .01
-
Prognostic role of ALK-1 and h-TERT expression in glioblastoma multiforme: correlation with ALK gene alterations
Journal of Pathology and Translational Medicine
2021 .01
-
EGFR 돌연변이와 ALK 재배열 공존하는 폐선암 환자 1예
대한내과학회지
2016 .01
-
ALK Protein Expression Is Related to Neuroblastoma Aggressiveness But Is Not Independent Prognostic Factor
Cancer Research and Treatment
2018 .01
-
SEC31A-ALKFusion Gene in Lung Adenocarcinoma
Cancer Research and Treatment
2016 .01
-
A case of concomitant EGFR/ALK alteration against a mutated EGFR background in early-stage lung adenocarcinoma
Journal of Pathology and Translational Medicine
2021 .01
-
Immunohistochemical expression of anaplastic lymphoma kinase in neuroblastoma and its relations with some clinical and histopathological features
Journal of Pathology and Translational Medicine
2024 .01
-
A Pooled Analysis on Crizotinib in Treating Chinese Patients with EML4-ALK Positive Non-small-cell Lung Cancer
Asian Pacific journal of cancer prevention : APJCP
2015 .01
-
Efficacy of Pemetrexed-based Chemotherapy in Comparison to Non-Pemetrexed-based Chemotherapy in Advanced, ALK+ Non-Small Cell Lung Cancer
Yonsei Medical Journal
2018 .01
-
Non-small Cell Lung Cancer with Concomitant EGFR, KRAS, and ALK Mutation: Clinicopathologic Features of 12 Cases
Journal of Pathology and Translational Medicine
2016 .01
-
Oral spindle cell/sclerosing rhabdomyosarcoma on mandible with anaplastic lymphoma kinase expression mimicking inflammatory myofibroblastic tumor
대한구강악안면외과학회지
2023 .04
-
Primary epithelioid inflammatory myofibroblastic sarcoma of the brain with EML4::ALK fusion mimicking intra-axial glioma: a case report and brief literature review
Journal of Pathology and Translational Medicine
2024 .05
-
Recent Topics in Fibrodysplasia Ossificans Progressiva
Endocrinology and Metabolism
2018 .01
-
Molecular Testing of Lung Cancers
Journal of Pathology and Translational Medicine
2017 .01
-
Prognostic and predictive markers in glioblastoma and ALK overexpression
Journal of Pathology and Translational Medicine
2021 .01
-
Clinical Features of Lung Cancer in Japanese Patients Aged Under 50
Asian Pacific journal of cancer prevention : APJCP
2016 .01
-
Crizotinib in Combination with Everolimus Synergistically Inhibits Proliferation of Anaplastic Lymphoma KinasePositive Anaplastic Large Cell Lymphoma
Cancer Research and Treatment
2018 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0