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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.1
- 수록면
- 262 - 266 (5page)
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The World Health Organization 2016 edition assigned anaplastic lymphoma kinase (ALK) rearrangement-associated renal cellcarcinoma (ALK-RCC) as an emerging renal tumor entity. Identifying ALK-RCC is important because ALK inhibitors have beenshown to be effective in treatment. Here, we report the case of a 14-year-old young man with ALK-RCC. Computed tomographyrevealed a well-demarcated 5.3-cm enhancing mass at the upper pole of the left kidney. There was no further history or symptomsof the sickle-cell trait. The patient underwent left radical nephrectomy. Pathologically, the mass was diagnosed as an unclassifiedRCC. Targeted next-generation sequencing identified a TPM3-ALK fusion gene. The present report and literature review demonstratethat TPM3-ALK RCC may be associated with distinct clinicopathological features. Microscopically, the tumors showed diffusegrowth and tubulocystic changes with inflammatory cell infiltration. Tumor cells were dis-cohesive and epithelioid with abundanteosinophilic cytoplasm and cytoplasmic vacuoles. If morphological features and TFE3 expression are present in adolescentand young patients, molecular tests for ALK translocation should be performed. This awareness is critically important, because ALKrearrangement confers sensitivity to ALK inhibitors.
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참고문헌 (15)
참고문헌 신청
Pulford K / 1997 / Detection of anaplastic lymphoma kinase(ALK)and nucleolar protein nucleophosmin(NPM)-ALK proteins in normal and neoplastic cells with the monoclonal antibody ALK1 / Blood 89:1394~1404
Hallberg B / 2013 / Mechanistic insight into ALK receptor tyrosine kinase in human cancer biology / Nat Rev Cancer 13:685~700
Trpkov K / 2019 / New and emerging renal entities : a perspective post-WHO 2016 classification / Histopathology 74:31~59
Sukov WR / 2012 / ALK alterations in adult renal cell carcinoma : frequency, clinicopathologic features and outcome in a large series of consecutively treated patients / Mod Pathol 25:1516~1525
Cajaiba MM / 2018 / The classification of pediatric and young adult renal cell carcinomas registered on the children’s oncology group(COG)protocol AREN03B2 after focused genetic testing / Cancer 124:3381~3389
Hallberg B / 2013 / Mechanistic insight into ALK receptor tyrosine kinase in human cancer biology / Nat Rev Cancer 13:685~700
Trpkov K / 2019 / New and emerging renal entities : a perspective post-WHO 2016 classification / Histopathology 74:31~59
Sukov WR / 2012 / ALK alterations in adult renal cell carcinoma : frequency, clinicopathologic features and outcome in a large series of consecutively treated patients / Mod Pathol 25:1516~1525
Cajaiba MM / 2018 / The classification of pediatric and young adult renal cell carcinomas registered on the children’s oncology group(COG)protocol AREN03B2 after focused genetic testing / Cancer 124:3381~3389
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