지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 1,338 - 1,350 (13page)
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Purpose TP53, the most frequently mutated gene in breast cancer, is more frequently altered in HER2-enriched and basal-like breast cancer. However, no studies have clarified the role of TP53 status as a prognostic and predictive marker of triple-negative breast cancer (TNBC).
Materials and Methods We performed p53 immunohistochemistry (IHC), nCounter mRNA expression assay, and DNA sequencing to determine the relationship between TP53 alteration and clinical outcomes of TNBC patients.
Results Seventy-seven of 174 TNBC patients were found to harbor a TP53 mutation. Patients with missense mutations showed high protein expression in contrast to patients with deletion mutations (positivity of IHC: wild type vs. missense vs. deletion mutation, 53.6% vs. 89.8% vs. 25.0%, respectively; p < 0.001). TP53 mRNA expression was influenced by mutation status (mRNA expression [median]: wild type vs. missense vs. deletion mutation, 207.36± 132.73 vs. 339.61±143.21 vs. 99.53±99.57, respectively; p < 0.001). According to survival analysis, neither class of mutation nor protein or mRNA expression status had any impact on patient prognosis. In subgroup analysis, low mRNA expression was associated with poor prognosis in patients with a TP53missense mutation (5-year distant recurrence-free survival [5Y DRFS]: low vs. high, 50.0% vs. 87.8%; p=0.009), while high mRNA expression with a TP53 deletion mutation indicated poor prognosis (5Y DRFS: low vs. high, 91.7% vs. 75.0%; p=0.316).
Conclusion Association between TP53mutation and expression indicates a potential prognostic marker of TNBC; hence both DNA sequencing and mRNA expression analysis may be required to predict the prognosis of TNBC patients.
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등록된 정보가 없습니다.
참고문헌 (28)
참고문헌 신청
Hainaut P / 2000 / p53 and human cancer : the first ten thousand mutations / Adv Cancer Res 77:81~137
Levine AJ / 1997 / p53, the cellular gatekeeper for growth and division / Cell 88:323~331
Sigal A / 2000 / Oncogenic mutations of the p53 tumor suppressor : the demons of the guardian of the genome / Cancer Res 60:6788~6793
Vogelstein B / 2000 / Surfing the p53 network / Nature 408:307~310
Xu X / 1999 / Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation / Nat Genet 22:37~43
Levine AJ / 1997 / p53, the cellular gatekeeper for growth and division / Cell 88:323~331
Sigal A / 2000 / Oncogenic mutations of the p53 tumor suppressor : the demons of the guardian of the genome / Cancer Res 60:6788~6793
Vogelstein B / 2000 / Surfing the p53 network / Nature 408:307~310
Xu X / 1999 / Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation / Nat Genet 22:37~43
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