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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제54권 제5호
- 발행연도
- 2020.1
- 수록면
- 378 - 386 (9page)
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Background: Recently, molecular classifications of gastric cancer (GC) have been proposed that include TP53 mutations and their functional activity. We aimed to demonstrate the correlation between p53 immunohistochemistry (IHC) and TP53 mutations as well as their clinicopathological significance in GC. Methods: Deep targeted sequencing was performed using surgical or biopsy specimens from 120 patients with GC. IHC for p53 was performed and interpreted as strong, weak, or negative expression. In 18 cases (15.0%) with discrepant TP53 mutation and p53 IHC results, p53 IHC was repeated. Results: Strong expression of p53 was associated with TP53 missense mutations, negative expression with other types of mutations, and weak expression with wild-type TP53 (p < .001). The sensitivity for each category was 90.9%, 79.0%, and 80.9%, and the specificity was 95.4%, 88.1%, and 92.3%, respectively. The TNM stage at initial diagnosis exhibited a significant correlation with both TP53 mutation type (p = .004) and p53 expression status (p = .029). The Kaplan-Meier survival analysis for 109 stage II and III GC cases showed that patients with TP53 missense mutations had worse overall survival than those in the wild-type and other mutation groups (p = .028). Strong expression of p53 was also associated with worse overall survival in comparison to negative and weak expression (p = .035). Conclusions: Results of IHC of the p53 protein may be used as a simple surrogate marker of TP53 mutations. However, negative expression of p53 and other types of mutations of TP53 should be carefully interpreted because of its lower sensitivity and different prognostic implications.
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참고문헌 (29)
참고문헌 신청
Junttila MR / 2009 / p53 : a Jack of all trades but master of none / Nat Rev Cancer 9:821~829
Bartkova J / 2005 / DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis / Nature 434:864~870
Starzynska T / 1992 / Prognostic significance of p53 overexpression in gastric and colorectal carcinoma / Br J Cancer 66:558~562
Kakeji Y / 1993 / Gastric cancer with p53overexpression has high potential for metastasising to lymph nodes / Br J Cancer 67:589~593
Maehara Y / 1999 / Prognostic value of p53protein expression for patients with gastric cancer : a multivariate analysis / Br J Cancer 79:1255~1261
Bartkova J / 2005 / DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis / Nature 434:864~870
Starzynska T / 1992 / Prognostic significance of p53 overexpression in gastric and colorectal carcinoma / Br J Cancer 66:558~562
Kakeji Y / 1993 / Gastric cancer with p53overexpression has high potential for metastasising to lymph nodes / Br J Cancer 67:589~593
Maehara Y / 1999 / Prognostic value of p53protein expression for patients with gastric cancer : a multivariate analysis / Br J Cancer 79:1255~1261
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