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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 156 - 163 (8page)
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Purpose The purpose of this study was to compare the treatment outcomes of definitive radiotherapy (RT) with cordectomy in patients with early glottic cancer. Materials and Methods A total of 165 patients who were diagnosed with T1/2 squamous cell carcinoma of the glottic larynx between January 2006 and December 2012 were retrospectively analyzed. A total of 112 patients received RT and 53 patients received cordectomy. Local control (LC), diseasefree survival (DFS), overall survival (OS), and larynx preservation rates after RT and cordectomy were investigated. Results The median follow-up period was 77.7 months (range, 10.7 to 127.0 months). The 3- and 5-year LC rates were 91.9% and 89.9%, respectively, for the RT group, and 82.8% and 73.2%, respectively, for the cordectomy group (p=0.006). The 3- and 5-year DFS rates were 87.5% and 83.7%, respectively, for the RT group and 79.2% and 68.0%, respectively, for the cordectomy group (p=0.046). No significant differences were identified in the 5-year OS (92.8% vs. 90.6%, p=0.713) or larynx preservation rates (98.2% vs. 97.2%, p=0.831) between groups. The major failure pattern was local failure (n=26), followed by regional (n=3) and distant failure (n=2). Multivariate analysis of LC showed that T2 stage (p=0.012) and receiving cordectomy as initial treatment (p=0.001) were significantly associated with poorer LC. Conclusion RT resulted in higher rates of LC and DFS compared to cordectomy for early glottic cancer. Treatment with radiotherapy is feasible and should be encouraged for both T1 and T2 glottic cancer.
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참고문헌 (20)
참고문헌 신청
Siegel RL / 2015 / Cancer statistics, 2015 / CA Cancer J Clin 65:5~29
Ries LA / 2006 / SEER cancer statistics review, 1975-2003
Mendenhall WM / 2001 / T1-T2N0 squamous cell carcinoma of the glottic larynx treated with radiation therapy / J Clin Oncol 19:4029~4036
Karatzanis AD / 2009 / Comparison among different available surgical approaches in T1 glottic cancer / Laryngoscope 119:1704~1708
Silver CE / 2009 / Current trends in initial management of laryngeal cancer: the declining use of open surgery / Eur Arch Otorhinolaryngol 266:1333~1352
Ries LA / 2006 / SEER cancer statistics review, 1975-2003
Mendenhall WM / 2001 / T1-T2N0 squamous cell carcinoma of the glottic larynx treated with radiation therapy / J Clin Oncol 19:4029~4036
Karatzanis AD / 2009 / Comparison among different available surgical approaches in T1 glottic cancer / Laryngoscope 119:1704~1708
Silver CE / 2009 / Current trends in initial management of laryngeal cancer: the declining use of open surgery / Eur Arch Otorhinolaryngol 266:1333~1352
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