지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 1,418 - 1,432 (15page)
이용수
초록· 키워드
오류제보하기
Purpose Alteration of biomarker status after primary systemic therapy (PST) is occasionally found in breast cancer. This study was conducted to clarify the clinical implications of change of biomarker status in breast cancer patients treated with PST. Materials and Methods The pre-chemotherapeutic biopsy and post-chemotherapeutic resection specimens of 442 breast cancer patients who had residual disease after PST were included in this study. The association between changes of biomarker status after PST and clinicopathologic features of tumors, and survival of the patients, were analyzed. Results Estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) status changed after PST in 18 (4.1%), 80 (18.1%), and 15 (3.4%) patients, respectively. ER and PR mainly underwent positive to negative conversion, whereas HER2 status underwent negative to positive conversion. Negative conversion of ER and PR status after PST was associated with reduced disease-free survival. Moreover, a decline in the Allred score for PR in post-PST specimens was significantly associated with poor clinical outcome of the patients. HER2 change did not have prognostic significance. In multivariate analyses, negative PR status after PST was found to be an independent adverse prognostic factor in the whole patient group, in the adjuvant endocrine therapy-treated subgroup, and also in pre-PST PR positive subgroup. Conclusion ER and HER2 status changed little after PST, whereas PR status changed significantly. In particular, negative conversion of PR status was revealed as a poor prognostic indicator, suggesting that re-evaluation of basic biomarkers is mandatory in breast cancer after PST for proper management and prognostication of patients.
목차
등록된 정보가 없습니다.
참고문헌 (30)
참고문헌 신청
Thompson AM / 2012 / Neoadjuvant treatment of breast cancer / Ann Oncol 23(Suppl 10):x231~x236
Ignatiadis M / 2015 / St Gallen International Expert Consensus on the primary therapy of early breast cancer: an invaluable tool for physicians and scientists / Ann Oncol 26:1519~1520
Senkus E / 2015 / Primary breast cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up / Ann Oncol 26(Suppl 5):v8~v30
Lee SH / 2003 / The effect of neoadjuvant chemotherapy on estrogen and progesterone receptor expression and hormone receptor status in breast cancer / Am J Surg 186:348~350
Makris A / 1999 / Quantitative changes in cytological molecular markers during primary medical treatment of breast cancer: a pilot study / Breast Cancer Res Treat 53:51~59
Ignatiadis M / 2015 / St Gallen International Expert Consensus on the primary therapy of early breast cancer: an invaluable tool for physicians and scientists / Ann Oncol 26:1519~1520
Senkus E / 2015 / Primary breast cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up / Ann Oncol 26(Suppl 5):v8~v30
Lee SH / 2003 / The effect of neoadjuvant chemotherapy on estrogen and progesterone receptor expression and hormone receptor status in breast cancer / Am J Surg 186:348~350
Makris A / 1999 / Quantitative changes in cytological molecular markers during primary medical treatment of breast cancer: a pilot study / Breast Cancer Res Treat 53:51~59
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
황정(黃精)과 증숙 황정(蒸熟 黃精)의 항산화, 항피로 효능 비교 연구
대한본초학회지(본초분과학회지)
2016 .01
-
Effect of Furosemide on Prevertebral Soft Tissue Swelling after Anterior Cervical Fusion: A Comparative Study with Dexamethasone
Asian Spine Journal
2024 .02
-
Invasive Lobular Carcinoma: MRI Features and Clinicohistological Characteristics According to the ER, PR, and HER Statuses
Investigative Magnetic Resonance Imaging
2015 .01
-
Breast Cancer Molecular Subtypes Defined by ER/PR and HER2 Status: Association with Clinicopathologic Parameters in Ivorian Patients
Asian Pacific journal of cancer prevention : APJCP
2016 .01
-
Sex Differences Associated With Hepatitis B Virus Surface Antigen Seropositivity Unwareness in Hepatitis B Virus Surface Antigen-positive Adults: 2007‐2012 Korea National Health and Nutrition Examination Survey
예방의학회지
2015 .01
-
The work–life balance and psychosocial well-being of South Korean workers
대한직업환경의학회지
2018 .07
-
Serous Adenocarcinoma of Fallopian Tubes: Histological and Immunohistochemical Aspects
Journal of Pathology and Translational Medicine
2019 .01
-
Reliability of Core Needle Biopsy in Evaluating Estrogen Receptor, Progesterone Receptor, and Human Epidermal Growth Factor Receptor 2, and Ki-67 Status
Journal of Breast Disease
2016 .12
-
A comparative study of the clinical characteristics of breast cancer patients less than 35 years old and older patients
KOREAN JOURNAL OF CLINICAL ONCOLOGY
2018 .06
-
Impact of COVID-19 on Clinicopathological Spectrum of Pityriasis Rosea in Korea
Journal of Korean Medical Science
2022 .06
-
Prognostic Value of Estrogen and Progesterone Receptor Expression in Low Proliferative Human Epidermal Growth Factor Receptor 2- Negative Breast Cancer
Journal of Breast Disease
2017 .12
-
Efficacy of Systemic Postoperative Pulmonary Rehabilitation After Lung Resection Surgery
Annals of Rehabilitation Medicine
2015 .01
-
Correlations between HER2 Expression and Other Prognostic Factors in Breast Cancer: Inverse Relations with the Ki-67 Index and P53 Status
Asian Pacific journal of cancer prevention : APJCP
2016 .01
-
Synchronous BI-RADS Category 3 Lesions on Preoperative Ultrasonography in Patients with Breast Cancer: Is Short-Term Follow-Up Appropriate?
Journal of Breast Cancer
2015 .01
-
Impact of Molecular Subtype Conversion of Breast Cancers after Neoadjuvant Chemotherapy on Clinical Outcome
Cancer Research and Treatment
2016 .01
-
Editorial : PRS Korea 2016 in Its 50th Anniversary
Archives of plastic surgery : APS
2016 .01
-
Automated immunohistochemical assessment ability to evaluate estrogen and progesterone receptor status compared with quantitative reverse transcription-polymerase chain reaction in breast carcinoma patients
Journal of Pathology and Translational Medicine
2021 .01
-
Pierre Robin Sequence 환아의 전신마취 하 치과 치료 증례 보고
International Journal of Disability and Oral Health
2019 .06
-
A comparative study of the clinical characteristics and outcomes of hormone receptor positive, HER2 negative breast cancer patients over 65 years old and under 65 years old patients
대한임상종양학회 학술대회지
2020 .07
-
Higher Expression of Toll-like Receptors 3, 7, 8, and 9 in Pityriasis Rosea
Journal of Pathology and Translational Medicine
2017 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0