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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제55권 제1호
- 발행연도
- 2021.1
- 수록면
- 33 - 42 (10page)
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초록· 키워드
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Background: This study aimed to investigate the capability of an automated immunohistochemical (IHC) evaluation of hormonal receptor status in breast cancer patients compared to a well-validated quantitative reverse transcription?polymerase chain reaction (RT-qPCR) method. Methods: This study included 93 invasive breast carcinoma cases that had both standard IHC assay and Oncotype Dx assay results. The same paraffin blocks on which Oncotype Dx assay had been performed were selected. Estrogen receptor (ER) and progesterone receptor (PR) receptor status were evaluated through IHC stains using SP1 monoclonal antibody for ER, and 1E2 monoclonal antibody for PR. All ER and PR immunostained slides were scanned, and invasive tumor areas were marked. Using the Quant-Center image analyzer provided by 3DHISTECH, IHC staining of hormone receptors was measured and converted to histochemical scores (H scores). Pearson correlation coefficients were calculated between Oncotype Dx hormone receptor scores and H scores, and between Oncotype Dx scores and Allred scores. Results: H scores measured by an automated imaging system showed high concordance with RT-qPCR scores. ER concordance was 98.9% (92/93), and PR concordance was 91.4% (85/93). The correlation magnitude between automated H scores and RT-qPCR scores was high and comparable to those of Allred scores (for ER, 0.51 vs. 0.37 [p = .121], for PR, 0.70 vs. 0.72 [p = .39]). Conclusions: Automated H scores showed a high concordance with quantitative mRNA expression levels measured by RT-qPCR.
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참고문헌 (24)
참고문헌 신청
Umemura S / 2006 / Immunohistochemical evaluation for hormone receptors in breast cancer : a practically useful evaluation system and handling protocol / Breast Cancer 13:232
Hammond ME / 2010 / American Society of Clinical Oncology/College of American Pathologists guideline recommendations for immunohistochemical testing of estrogen and progesterone receptors in breast cancer (unabridged version) / Arch Pathol Lab Med. 134:e48~e72
Paik S / 2004 / A multigene assay to predict recurrence of tamoxifen-treated, node-negative breast cancer / N Engl J Med 351:2817~2826
Xin L / 2017 / The era of multigene panels comes? The clinical utility of Oncotype DX and MammaPrint / World J Oncol 8:34~40
O’Connor SM / 2010 / Concordance between semiquantitative immunohistochemical assay and oncotype DX RT-PCR assay for estrogen and progesterone receptors / Appl Immunohistochem Mol Morphol 18:268~272
Hammond ME / 2010 / American Society of Clinical Oncology/College of American Pathologists guideline recommendations for immunohistochemical testing of estrogen and progesterone receptors in breast cancer (unabridged version) / Arch Pathol Lab Med. 134:e48~e72
Paik S / 2004 / A multigene assay to predict recurrence of tamoxifen-treated, node-negative breast cancer / N Engl J Med 351:2817~2826
Xin L / 2017 / The era of multigene panels comes? The clinical utility of Oncotype DX and MammaPrint / World J Oncol 8:34~40
O’Connor SM / 2010 / Concordance between semiquantitative immunohistochemical assay and oncotype DX RT-PCR assay for estrogen and progesterone receptors / Appl Immunohistochem Mol Morphol 18:268~272
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