Prognostic Value of Estrogen and Progesterone Receptor Expression in Low Proliferative Human Epidermal Growth Factor Receptor 2- Negative Breast Cancer

이유진; 박인석; 조현진; 양근호; 김정빈; 박경미; 곽금희

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자료유형: 학술저널

저자정보: 이유진 (인제대학교) 박인석 (인제대학교) 조현진 (인제대학교) 양근호 (인제대학교) 김정빈 (인제대학교 의과대학 상계백병원 외과학교실) 박경미 (인제대학교 의과대학 상계백병원 병리과) 곽금희 (인제대학교 의과대학 상계백병원 외과학교실)

저널정보: 한국유방암학회 Journal of Breast Disease Journal of Breast Disease 제5권 제2호

발행연도: 2017.12

수록면: 64 - 70 (7page)

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Purpose: Approximately two-thirds of breast cancer are estrogen-dependent cancers, which express estrogen receptor (ER)/progesterone receptor (PR). We investigated the prognostic value of ER/PR expression in human epidermal growth factor receptor 2 (HER2)-negative and low proliferative (Ki-67 ≤20%) breast cancer. Methods: A retrospective review was performed of 252 breast cancer data records, identified as ER/PR-positive, low Ki-67 proliferation index (≤20%) and HER2-negative. The data were divided into two subgroups: a strong luminal subgroup and a weak luminal subgroup, according to hormonal receptor expression status. Outcome measures included age at diagnosis, tumor size, tumor-node-metastasis (TNM) stage, ER, PR, Bcl-2, recurrent or metastatic characteristics, disease-free survival and overall survival, of each subgroup. Results: There were no statistical differences in TNM stage or tumor numbers between the two subgroups. The strong luminal subgroup was associated with a higher Bcl-2 expression (p<0.001). The weak luminal subgroup was associated with more frequent neural invasion (p=0.051) and lung (p=0.031), liver (p=0.031) and brain (p=0.033) metastases, than the strong luminal subgroup. Disease-free survival was significantly longer in the strong luminal subgroup than weak luminal subgroup (p=0.015). Overall survival was also significantly improved in the strong luminal subgroup relative to the weak luminal subgroup (p=0.014). Conclusion: The weak luminal subgroup showed worse prognosis than the strong luminal subgroup, among ER/PR-positive HER2-negative low proliferative breast cancer patients. Weak ER or PR expression, can be considered a poor prognostic factor in ER/PR-positive HER2-negative low proliferative breast cancer.

#Breast neoplasms #Estrogen receptors #Progesterone receptors #Prognosis

참고문헌 (2)

참고문헌 신청

Han-Sung Kim / 2012 / Analysis of the Potent Prognostic Factors in Luminal-Type Breast Cancer / Journal of Breast Cancer 15(4):401~406

박경미 / 2011 / Silver-Enhanced In Situ Hybridization as an Alternative to Fluorescence In Situ Hybridization for Assaying HER2 Amplification in Clinical Breast Cancer / Journal of Breast Cancer 14(4):276~282

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