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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 128 - 131 (4page)
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Translocations leading to fusions between the immunoglobulin heavy chain gene (IGH) and various partner genes have been reported in B-cell precursor acute lymphoblastic leukemia (B-ALL). However, submicroscopic deletions within IGH in B-ALL have not been rigorously assessed. In this study, we investigated characteristics of IGH submicroscopic deletions, by FISH, in B-ALL with IGH rearrangements. FISH was performed by using commercially available IGH dual-color break-apart rearrangement probes (Abbott/Vysis, Downers Grove, IL, USA; Kreatech, Amsterdam, Netherlands). The study group included seven B-ALL patients with IGH rearrangements, observed by FISH. Among them, two exhibited deletion of the 5´ variable region of IGH by FISH. The B-ALL in these two patients included two kinds of abnormal cells; one had an IGH rearrangement without any IGH submicroscopic deletion, while the other had an IGH submicroscopic deletion, which showed that one normal fusion signal and one 3´ IGH signal were detected. Thus, submicroscopic deletion of the IGH 5´ variable region may have occurred in either the native or rearranged chromosome 14. These findings indicate that B-ALL with IGH rearrangements may be accompanied by submicroscopic deletions of the IGH 5´ variable region, which can be detected by FISH. The clinical significance of such deletions is unclear, but the loss of part of the IGH gene in B-ALL warrants further study.
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참고문헌 (17)
참고문헌 신청
Akasaka T / 2007 / Five members of the CEBP transcription factor family are targeted by recurrent IGH translocations in B-cell precursor acute lymphoblastic leukemia (BCP-ALL
Chapiro E / 2013 / Chromosomal translocations involving the IGH@ locus in B-cell precursor acute lymphoblastic leukemia: 29 new cases and a review of the literature / Cancer
Dyer MJ / 1993 / Unusual deletions within the immunoglobulin heavy-chain locus in acute leukemias / Blood 82 : 865 ~ 871
Dyer MJ / 2010 / Immunoglobulin heavy chain locus chromosomal translocations in B-cell precursor acute lymphoblastic leukemia: rare clinical curios or potent genetic drivers?
Fink SR / 2005 / Fluorescent-labeled DNA probes applied to novel biological aspects of B-cell chronic lymphocytic leukemia / Leuk Res 29 : 253 ~ 262
Chapiro E / 2013 / Chromosomal translocations involving the IGH@ locus in B-cell precursor acute lymphoblastic leukemia: 29 new cases and a review of the literature / Cancer
Dyer MJ / 1993 / Unusual deletions within the immunoglobulin heavy-chain locus in acute leukemias / Blood 82 : 865 ~ 871
Dyer MJ / 2010 / Immunoglobulin heavy chain locus chromosomal translocations in B-cell precursor acute lymphoblastic leukemia: rare clinical curios or potent genetic drivers?
Fink SR / 2005 / Fluorescent-labeled DNA probes applied to novel biological aspects of B-cell chronic lymphocytic leukemia / Leuk Res 29 : 253 ~ 262
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