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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.7
- 수록면
- 331 - 335 (5page)
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Minimal residual disease (MRD) following B-lymphoblastic leukemia (B-ALL) treatment has gained prognostic importance. Clonal immunoglobulin heavy chain (IGH) gene rearrangement is a useful follow-up marker in B-ALL owing to its high positivity rate. We evaluated the performance and clinical applicability of a next-generation sequencing (NGS) assay for IGH rearrangement in B-ALL MRD monitoring. IGH rearrangement was tested by using fluorescence PCR-fragment analysis and the NGS assay in eight B-ALL patients. The NGS assay was run on two platforms: the Ion Torrent PGM (Thermo Fisher Scientific, USA) (18 samples from 1st to 7th patients) and the MiSeq system (Illumina, USA) (four samples from 8th patient). All initial diagnostic samples and four follow-up samples were positive for clonal IGH rearrangement with fluorescence PCR-fragment analysis and the NGS assay, and six follow-up samples were positive only with NGS. In one case with BCR-ABL1 translocation, BCR-ABL1 quantitative PCR was negative but the NGS IGH assay was positive just prior to full-blown relapse, suggesting the high sensitivity and clinical utility of the NGS assay. The NGS assay is proposed for MRD monitoring in B-ALL Additional studies are needed to confirm the clinical implications of cases showing positive results only in NGS.
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참고문헌 (14)
참고문헌 신청
Borowitz MJ / 2008 / Clinical significance of minimal residual disease in childhood acute lymphoblastic leukemia and its relationship to other prognostic factors: a Children’s Oncology Group study / Blood 111:5477~5485
Logan AC / 2014 / Immunoglobulin and T cell receptor gene high-throughput sequencing quantifies minimal residual disease in acute lymphoblastic leukemia and predicts post-transplantation relapse and survival / Biol Blood Marrow Transplant 20:1307~1313
Bassan R / 2009 / Improved risk classification for risk-specific therapy based on the molecular study of minimal residual disease (MRD) in adult acute lymphoblastic leukemia (ALL) / Blood 113:4153~4162
Schwartz RS / 2003 / Shattuck lecture: Diversity of the immune repertoire and immunoregulation / N Engl J Med 348:1017~1026
Grove CS / 2014 / Acute myeloid leukaemia: a paradigm for the clonal evolution of cancer? / Dis Model Mech 7:941~951
Logan AC / 2014 / Immunoglobulin and T cell receptor gene high-throughput sequencing quantifies minimal residual disease in acute lymphoblastic leukemia and predicts post-transplantation relapse and survival / Biol Blood Marrow Transplant 20:1307~1313
Bassan R / 2009 / Improved risk classification for risk-specific therapy based on the molecular study of minimal residual disease (MRD) in adult acute lymphoblastic leukemia (ALL) / Blood 113:4153~4162
Schwartz RS / 2003 / Shattuck lecture: Diversity of the immune repertoire and immunoregulation / N Engl J Med 348:1017~1026
Grove CS / 2014 / Acute myeloid leukaemia: a paradigm for the clonal evolution of cancer? / Dis Model Mech 7:941~951
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