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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2015.1
- 수록면
- 570 - 577 (8page)
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초록· 키워드
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Background: Soluble suppression of tumorigenicity 2 (sST2) has emerged as a novel biomarker for heart failure, and serum sST2 concentrations could be increased in inflammatory diseases. We explored whether sST2 is related to cardiac dysfunction/failure and has a prognostic role in patients with suspected sepsis.
Methods: In a total of 397 patients with suspected sepsis, sST2 concentrations were measured by using the Presage ST2 Assay (Critical Diagnostics, USA). sST2 concentrations were analyzed according to procalcitonin (PCT) concentrations, cardiovascular subscores of the sepsis-related organ failure assessment (SOFA) score, and clinical outcomes.
Results: sST2 concentrations were increased significantly according to the five groups of PCT concentrations and cardiovascular subscores of the SOFA score (P<0.000001 and P=0.036, respectively). In-hospital mortality was significantly higher among patients with sST2 concentrations above 35 ng/mL (P=0.0213) and among patients with increased concentrations of both sST2 and PCT (P=0.0028).
Conclusions: sST2 seems to be related to both cardiac dysfunction/failure and severity in sepsis. Measurement of sST2 and PCT in combination would be useful for risk stratification and prognosis prediction in patients with suspected sepsis.
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등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
/ / http://www.accessdata.fda.gov/cdrh_docs/reviews/k111452.pdf
Alves-Filho JC / 2010 / Interleukin-33 attenuates sepsis by enhancing neutrophil influx to the site of infection / Nat Med 16 : 708 ~ 712
Brunner M / 2004 / Increased levels of soluble ST2 protein and IgG1 production in patients with sepsis and trauma / Intensive Care Med 30 : 1468 ~ 1473
Dellinger RP / 2013 / Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock, 2012 / Intensive Care Med 39 : 165 ~ 228
Di Somma S / 2013 / Opinion paper on innovative app
Brunner M / 2004 / Increased levels of soluble ST2 protein and IgG1 production in patients with sepsis and trauma / Intensive Care Med 30 : 1468 ~ 1473
Dellinger RP / 2013 / Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock, 2012 / Intensive Care Med 39 : 165 ~ 228
Di Somma S / 2013 / Opinion paper on innovative app
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