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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.1
- 수록면
- 501 - 503 (3page)
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Dear Editor, Rearrangements involving mixed lineage leukemia (MLL) are common chromosome aberrations in infant, pediatric and adult acute leukemia, which are generally associated with poor prognosis. To date, more than 79 partner genes have been identified [1]. MLL fusion partners can be classified into four groups: nuclear proteins (MLLT3, MLLT10, and MLLT1), cytoplasmatic proteins (GAS7, SH3GL1, EPS15, and MLLT4), histone acetyltransferases (EP300, CREBBP), and the septin family (SEPT2, SEPT5, and SEPT6) [2]. In pediatric and adult AML, the most frequent fusion partners are represented by MLLT3-AF9 (9p22), MLLT10-AF10 (10p12), ELL (19p13.1), MLLT4-AF6 (6q27), and MLLT1-ENL (19p13.3) [1, 3]. However, as a partner gene, the SEPT5 gene has been reported in only five AML cases (Table 1).
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참고문헌 (10)
참고문헌 신청
Meyer C / 2013 / The MLL recombinome of acute leukemias in 2013 / Leukemia 27:2165~2176
Cerveira N / 2011 / MLL-SEPTIN gene fusions in hematological malignancies / Biol Chem 392:713~724
Meyer C / 2009 / New insights to the MLL recombinome of acute leukemias / Leukemia 23:1490~1499
John Jeongseok Yang / 2012 / Diagnostic Usefulness of Genomic Breakpoint Analysis of Various Gene Rearrangements in Acute Leukemias: A Perspective of Long Distance– or Long Distance Inverse-PCR–based Approaches / Annals of Laboratory Medicine 32(4):316~318
Tatsumi K / 2001 / The CDCREL1 gene fused to MLL in de novo acute myeloid leukemia with t(11;22)(q23;q11.2) and its frequent expression in myeloid leukemia cell lines / Genes Chromosomes Cancer 30:230~235
Cerveira N / 2011 / MLL-SEPTIN gene fusions in hematological malignancies / Biol Chem 392:713~724
Meyer C / 2009 / New insights to the MLL recombinome of acute leukemias / Leukemia 23:1490~1499
John Jeongseok Yang / 2012 / Diagnostic Usefulness of Genomic Breakpoint Analysis of Various Gene Rearrangements in Acute Leukemias: A Perspective of Long Distance– or Long Distance Inverse-PCR–based Approaches / Annals of Laboratory Medicine 32(4):316~318
Tatsumi K / 2001 / The CDCREL1 gene fused to MLL in de novo acute myeloid leukemia with t(11;22)(q23;q11.2) and its frequent expression in myeloid leukemia cell lines / Genes Chromosomes Cancer 30:230~235
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