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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.1
- 수록면
- 204 - 212 (9page)
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초록· 키워드
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Background: The aims of this study were to investigate the parameters of thromboelastography (TEG) for evaluating coagulopathy and to reveal an association with disease severity and/or transfusion requirement in patients with chronic liver disease (CLD) in a clinical laboratory setting.
Methods: We enrolled two groups of adult patients with cirrhotic (N=123) and non-cirrhotic liver disease (N=52), as well as 84 healthy controls. Reaction time (R), kinetic time (K), α-angle (α), maximal amplitude (MA), and coagulation index (CI) were measured with kaolin-activated citrated blood with the TEG 5000 system (Haemonetics Corporation, USA). Platelet count, prothrombin time international normalized ratio (PT INR), albumin, bilirubin, and creatinine were simultaneously measured. The CLD severity was calculated by using the Child-Pugh (C-P) and Model for End-stage Liver Disease (MELD) scores. Transfusion history was also reviewed.
Results: All TEG parameters, PT INR, and platelet count in the cirrhotic group showed significant differences from those in other groups. At least one or more abnormal TEG parameters were identified in 17.3% and 44.7% of patients in the non-cirrhotic and cirrhotic group, respectively. Patients with cirrhotic disease had hypocoagulability. A weak correlation between R and PT INR (r=0.173) was noted. The TEG parameters could not predict CLD severity using the C-P and MELD scores. Patients with normal TEG parameters did not receive transfusion.
Conclusions: Clinical application of TEG measurements in CLD can be informative for investigating coagulopathy or predicting the risk of bleeding. Further studies are warranted.
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참고문헌 (24)
참고문헌 신청
Amitrano L / 2002 / Coagulation disorders in liver disease / Semin Liver Dis 22 : 83 ~ 96
Basili S / 2010 / The coagulopathy of chronic liver disease : is there a causal relationship with bleeding? Yes / Eur J Intern Med 21 : 62 ~ 64
Bolliger D / 2012 / Principles and practice of thromboelastography in clinical coagulation management and transfusion practice / Transfus Med Rev 26 : 1 ~ 13
Caldwell SH / 2006 / Coagulation disorders and hemostasis in liver disease: pathophysiology and critical assessment of current management / Hepatology 44 : 1039 ~ 1046
Chau TN / 1998 / Thrombelastographic changes and early rebleeding in cirrhotic patients with variceal bleeding / Gut 43 : 267 ~ 271
Basili S / 2010 / The coagulopathy of chronic liver disease : is there a causal relationship with bleeding? Yes / Eur J Intern Med 21 : 62 ~ 64
Bolliger D / 2012 / Principles and practice of thromboelastography in clinical coagulation management and transfusion practice / Transfus Med Rev 26 : 1 ~ 13
Caldwell SH / 2006 / Coagulation disorders and hemostasis in liver disease: pathophysiology and critical assessment of current management / Hepatology 44 : 1039 ~ 1046
Chau TN / 1998 / Thrombelastographic changes and early rebleeding in cirrhotic patients with variceal bleeding / Gut 43 : 267 ~ 271
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